Aceclofenac

M01A - NSAIDs and antirheumatic products, non-steroids ATC M01AB16 Small molecule Natural product

🧬 Cross-allergy: NSAIDs

JFDA label: AIRTAL TABLET

Mechanism of Action

Inhibitor of Prostaglandin G/H synthase 2 — Cyclooxygenase-2 inhibitor

Target	Action	Gene / class
Prostaglandin G/H synthase 2 efficacy	INHIBITOR	PTGS2

Indications

Approved

Arthralgia — Arthralgia
Arthritis, Rheumatoid — rheumatoid arthritis
Myalgia — Myalgia
Osteoarthritis — osteoarthritis
Rheumatic Diseases — rheumatic disease
Spondylitis — spondylitis

Off-label

Pulpitis

Class profile

cox1_IC50_uM	2.0
cox2_IC50_uM	0.3
cox2_selectivity	6.666666666666667
inhibitionType	reversible
preferentialCOX2	1
selectiveCOX2	0
plateletEffect	0
source	Warner1999/Vane1996/ChEMBL

Pregnancy & Lactation

Pregnancy

Lactation

Compatible Hale L1

If a mother requires aceclofenac, it is not a reason to discontinue breastfeeding; however, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Monitoring

Efficacy	Pain and inflammation control (VAS/NRS scores, joint mobility, functional status); minimum effective dose
Toxicity	Blood pressure (raises BP, antagonises antihypertensives); renal function (SCr, eGFR — especially in elderly, heart failure, CKD, dehydrated); Hb/faecal occult blood (GI bleeding); LFTs; oedema
Clinical pearl	Use the lowest effective dose for the shortest duration. Consider co-prescribing a proton pump inhibitor if GI risk factors present. COX-2 selective agents reduce GI but not CV risk.
Counseling	Take with food or milk to reduce GI upset. Report black stools, blood in urine, or significant ankle swelling. Monitor blood pressure regularly if hypertensive.

Chemistry & Properties

Formula	C16H13Cl2NO4
Molecular weight	354.19 g/mol
IUPAC name	2-[2-[2-(2,6-dichloroanilino)phenyl]acetyl]oxyacetic acid
CAS	89796-99-6
PubChem CID	71771
InChIKey	`MNIPYSSQXLZQLJ-UHFFFAOYSA-N`
logP	3.91 (XLogP 4.3)
Polar surface area	75.63 Å²
H-bond acceptors / donors	4 / 2
Drug-likeness (QED)	0.77
Lipinski violations	0

SMILES

O=C(O)COC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl

Biology & Pharmacokinetics

Pharmacokinetics

BBB penetrant	No

Enzyme interactions

Enzyme	Role	Detail
CYP1A2	Substrate	—
CYP2B6	Inhibitor	—
CYP2B6	Substrate	—
CYP2C19	Substrate	—
CYP2C9	Inhibitor	—
CYP2C9	Substrate	—
CYP3A4	Substrate	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)MRP3 (Inhibitor)MRP4 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (2)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
AIRTAL TABLET	Tablet 100 mg	10 tab pack varies	THE ARAB DRUG STORE P.S.C	1.270
AIRTAL TABLET	Tablet 100 mg	40 tab pack varies	THE ARAB DRUG STORE P.S.C	4.740