Ambroxol
R05C - Expectorants, excl. combinations with cough suppressants
ATC R05CB06
Small molecule
Natural product
JFDA label: Mucoram syrup
Indications
Off-label
- Amyotrophic Lateral Sclerosis
- Cough
- Dementia
- Gaucher Disease
- Parkinson Disease
- Pharyngitis
- Respiratory Tract Diseases
Pregnancy & Lactation
Pregnancy
Lactation
Compatible
Hale L1
If a mother requires ambroxol, it is not a reason to discontinue breastfeeding; however, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Chemistry & Properties
| Formula | C13H18Br2N2O |
|---|---|
| Molecular weight | 378.11 g/mol |
| IUPAC name | 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol |
| CAS | 18683-91-5 |
| PubChem CID | 2132 |
| InChIKey | JBDGDEWWOUBZPM-XYPYZODXSA-N |
| logP | 3.19 (XLogP 2.6) |
| Polar surface area | 58.28 Ų |
| H-bond acceptors / donors | 3 / 3 |
| Drug-likeness (QED) | 0.71 |
| Lipinski violations | 0 |
SMILES
Nc1c(Br)cc(Br)cc1CN[C@H]1CC[C@H](O)CC1Biology & Pharmacokinetics
Pharmacokinetics
| BBB penetrant | No |
|---|
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP2B6 | Inhibitor | — |
| CYP2C8 | Inhibitor | — |
| CYP2D6 | Inhibitor | IC₅₀ 0.5573999999999999 µM |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (22)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Fedecol syrup | Syrup 15 mg/5 ml | 100 ml | Pharma International Company/ Jordan | 0.980 |
| Ambolar | Syrup 15 mg/5 ml | 100 ml | Dar Al Dawa Development and Investment Co Ltd/Jordan | 1.250 |
| Broncolite | Solution 0.3 % | 100 ml | Hayat Pharmaceutical Industries CO.PLC/JORDAN | 1.250 |
| Mucoram syrup | Syrup 15 mg/5 ml | 100 ml | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 1.250 |
| Amrox Liquid | Solution 0.3 % | 100 ml pack varies | JERASH PHARMACEUTICALS LTD.CO/JORDAN | 1.430 |
| Mucol Syrup | Syrup 0.3 % | 100 ml pack varies | Amman Pharmaceutical Indusries | 1.650 |
| Amrox Liquid | Solution 0.3 % | 120 ml pack varies | JERASH PHARMACEUTICALS LTD.CO/JORDAN | 1.700 |
| Fluibron Syrup | Syrup 3 mg/ml | 100 ml pack varies | Hayat Pharmaceutical Industries CO.PLC/JORDAN | 2.060 |
| Ambolar 30mg/ | Syrup 30 mg/5 ml | 100 ml | Dar Al Dawa Development and Investment Co Ltd/Jordan | 2.130 |
| Fluibron Tab | Tablet 30 mg | 30 tab | Hayat Pharmaceutical Industries CO.PLC/JORDAN | 2.160 |
| Mucosolvan Tab | Tablet 30 mg | 20 tab | THE ARAB DRUG STORE P.S.C | 2.240 |
| Muzil | Suspension 30 mg/5 ml | 100 MILLILITER | Sukhtian Group | 2.350 |
| Amrox Forte | Solution 0.6 g/100 ml BOT | 100 ml pack varies | Jerash Pharmaceutical Company | 2.430 |
| Fluibron DS | Solution 0.6 % | 100 ml pack varies | Hayat Pharmaceutical Industries CO.PLC/JORDAN | 2.550 |
| Fluibron Syrup | Syrup 3 mg/ml | 125 ml pack varies | Hayat Pharmaceutical Industries CO.PLC/JORDAN | 2.570 |
| Amrox Forte | Solution 0.6 g/100 ml BOT | 120 ml pack varies | Jerash Pharmaceutical Company | 2.890 |
| Mucoram Tablet | Tablet 30 mg | 30 tab | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 2.900 |
| Fluibron DS | Solution 0.6 % | 125 ml pack varies | Hayat Pharmaceutical Industries CO.PLC/JORDAN | 2.940 |
| Mucosolvan | Suspension 30 mg/5 ml | 100 ml | THE ARAB DRUG STORE P.S.C | 3.090 |
| Mucol Syrup | Syrup 0.3 % | 200 ml pack varies | Amman Pharmaceutical Indusries | 3.130 |
| Mucosolvan L.A Cap | Capsule 75 mg | 10 cap | THE ARAB DRUG STORE P.S.C | 3.240 |
| Amrox Forte | Solution 0.6 g/100 ml BOT | 250 ml pack varies | Jerash Pharmaceutical Company | 5.770 |