Biotin
A11H - Other plain vitamin preparations
ATC A11HA05
Small molecule
approved 1985
Parenteral
Natural product
JFDA label: Sana Biotin
Mechanism of Action
Functions as a coenzyme; involved in carboxylation, transcarboxylation, and decarboxylation reactions of gluconeogenesis, lipogenesis, fatty acid synthesis, propionate metabolism, and the catabolism of leucine
Indications
Approved
- Anemia — anemia (phenotype)
- Anemia, Iron-Deficiency — Iron deficiency anemia
- Diabetes Mellitus, Type 2 — type 2 diabetes mellitus
- Kidney Failure, Chronic — chronic kidney disease
Off-label
- Amyotrophic Lateral Sclerosis
- Anemia, Neonatal
- Asthma
- Heart Failure
- Huntington Disease
- Multiple Sclerosis
Pregnancy & Lactation
Pregnancy
Chemistry & Properties
| Formula | C10H16N2O3S |
|---|---|
| Molecular weight | 244.32 g/mol |
| IUPAC name | 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid |
| CAS | 58-85-5 |
| PubChem CID | 171548 |
| InChIKey | YBJHBAHKTGYVGT-ZKWXMUAHSA-N |
| logP | 0.8 (XLogP 0.3) |
| Polar surface area | 78.43 Ų |
| H-bond acceptors / donors | 3 / 3 |
| Drug-likeness (QED) | 0.49 |
| Lipinski violations | 0 |
SMILES
O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21Biology & Pharmacokinetics
Pharmacokinetics
| BBB penetrant | Yes |
|---|
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP2C9 | Substrate | — |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MDR1 (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)OATP1B3 (Inhibitor)OCT1 (Inhibitor)P-gp (Inhibitor)MCT1 (Substrate)MDR1 (Substrate)P-gp (Substrate)PEPT1 (Substrate)
Registered Products (9)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Vitadad B. Forte Tablet | Tablet 50 mg, 25 mg, 0.15 mg, 15 mg, 15 mg, 10 mg, 10 mcg | 30 tab pack varies | Dar Al Dawa Development and Investment Co Ltd/Jordan | 2.000 |
| BECOZYM FORTE TAB | Tablet 50 mg, 25 mg, 0.15 mg, 0.01 mg, 10 mg, 15 mg, 15 mg | 20 tab | The Jordan Drugstore Co | 2.270 |
| Mamera Caplet | Tablet 1 mg, 30 mcg, 100 mg, 30 IU, 3000 IU, 200 IU, 3 mg, 3.4 mg, 20 mg, 20 mcg, 10 mg, 12 mcg, 200 mg, 25 mcg, 150 mcg, 25 mcg, 22.5 mg, 27 mg, 2 mg, 10 mg, 25 mg, 2.3 mg | 30 tab | Jordan Sweden Medical & Sterilization Co. | 2.420 |
| Pronatal | Tablet 0.6 mg, 2.6 mcg, 18 mg, 0.03 mg, 2 mg, 85 mg, 15 mg, 0.06 mg, 150 mg, 0.03 mg, 0.2 mg, 0.05 mg, 11 mg, 1.9 mg, 27 mg, 1 mg, 53 mg, 1.4 mg, 200 IU, 1.4 mg | 30 tab | THE ARAB DRUG STORE P.S.C | 5.570 |
| Elevit Pronatal film-coated tablets | Film-Coated Tablet 0.80 mg, 4.00 mcg, 19.00 mg, 10.00 mg, 200 mcg, 100.00 mg, 1080 mcg, 12.5 mcg, 125.00 mg, 7.50 mg, 2.60 mg, 60.00 mg, 1.00 mg, 125 mg, 1.00 mg, 1.80 mg, 100.00 mg, 1.60 mg, 15.00 mg | 30 tab | The Jordan Drugstore Co | 8.330 |
| Sana Biotin | Capsule 10 mg | 60 cap pack varies | SANA PHARMACEUTICAL INDUSTRY/JORDAN | 11.870 |
| Sana Biotin | Capsule 10 mg | 120 cap pack varies | SANA PHARMACEUTICAL INDUSTRY/JORDAN | 17.150 |
| Vitadad B Forte Tablet | Tablet 50 mg, 25 mg, 0.15 mg, 15 mg, 15 mg, 10 mg, 10 mcg | 300 tab | Dar Al Dawa Development and Investment Co Ltd/Jordan | 18.000 |
| Vitadad B. Forte Tablet | Tablet 50 mg, 25 mg, 0.15 mg, 15 mg, 15 mg, 10 mg, 10 mcg | 500 tab pack varies | Dar Al Dawa Development and Investment Co Ltd/Jordan | 29.000 |