Bromhexine
R05C - Expectorants, excl. combinations with cough suppressants
ATC R05CB02
Small molecule
Natural product
JFDA label: Mucolan syrup
Mechanism of Action
— Unknown
Indications
Off-label
- Severe Acute Respiratory Syndrome
Adverse Reactions
Very Common >10%Common 1–10%Uncommon 0.1–1%
Rare 0.01–0.1%Very Rare <0.01%Not Known
Immune system disorders (3)
Not Known Anaphylactic shock · Hypersensitivity · Immune system disorder
Gastrointestinal disorders (5)
Not Known Abdominal pain upper · Diarrhoea · Gastrointestinal disorder · Nausea · Vomiting
Skin and subcutaneous tissue disorders (6)
Not Known Angioedema · Dermatitis · Pruritus · Rash · Skin disorder · Urticaria
Respiratory, thoracic and mediastinal disorders (1)
Not Known Bronchospasm
Pregnancy & Lactation
Pregnancy
Lactation
Compatible
Hale L1
If a mother requires bromhexine, it is not a reason to discontinue breastfeeding; however, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Chemistry & Properties
| Formula | C14H20Br2N2 |
|---|---|
| Molecular weight | 376.14 g/mol |
| IUPAC name | 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline |
| CAS | 3572-43-8 |
| PubChem CID | 2442 |
| InChIKey | OJGDCBLYJGHCIH-UHFFFAOYSA-N |
| logP | 4.56 (XLogP 4.3) |
| Polar surface area | 29.26 Ų |
| H-bond acceptors / donors | 2 / 1 |
| Drug-likeness (QED) | 0.78 |
| Lipinski violations | 0 |
SMILES
CN(Cc1cc(Br)cc(Br)c1N)C1CCCCC1Biology & Pharmacokinetics
Pharmacokinetics
| BBB penetrant | No |
|---|
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP2B6 | Inhibitor | — |
| CYP2C19 | Inhibitor | — |
| CYP2C19 | Substrate | — |
| CYP2C8 | Inhibitor | — |
| CYP2C9 | Inhibitor | — |
| CYP2D6 | Inhibitor | IC₅₀ 0.19579999999999997 µM |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (8)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Mucolyte Tablet | Tablet 8 mg | 20 tab | Professional Drug Store | 0.610 |
| Bromosolvon | Suspension 4 mg/5 ml | 100 ml pack varies | Al-Gadeed Pharmaceutical Industries/JORDAN | 0.900 |
| Bromosolvon | Suspension 4 mg/5 ml | 200 ml pack varies | Al-Gadeed Pharmaceutical Industries/JORDAN | 0.900 |
| Mucolan syrup | Syrup 5 mg/5 ml | 100 ml | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 0.900 |
| Solvexin syrup | Syrup 4 mg/5 ml | 100 ml | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 0.900 |
| Mucofree syrup | Syrup 4 mg/5 ml | 100 ml | JORDAN RIVER PHARMA.IND(JORIVER)/JORDAN | 0.970 |
| Riaxine | Suspension 4 mg/5 ml | 100 ml | Khoury Drug Store | 1.610 |
| BISOLVON Tab. | Tablet 8 mg | 20 tab | THE ARAB DRUG STORE P.S.C | 1.890 |