Butamirate

JFDA label: Sinecod drops

Indications

Off-label

• Cough

Chemistry & Properties

Formula	C18H29NO3
Molecular weight	307.43 g/mol
IUPAC name	2-[2-(diethylamino)ethoxy]ethyl 2-phenylbutanoate
CAS	18109-80-3
PubChem CID	28892
InChIKey	DDVUMDPCZWBYRA-UHFFFAOYSA-N
logP	3.08 (XLogP 3.3)
Polar surface area	38.77 Ų
H-bond acceptors / donors	4 / 0
Drug-likeness (QED)	0.47
Lipinski violations	0

SMILES

CCC(C(=O)OCCOCCN(CC)CC)c1ccccc1

Biology & Pharmacokinetics

Pharmacokinetics predicted

Bioavailability	70.0%
Half-life	0.883 h
Volume of distribution	2.216 L/kg
Protein binding	49.4%
BBB penetrant	No

Enzyme interactions

Enzyme	Role	Detail
CYP2B6	Inhibitor	—
CYP2D6	Inhibitor	—
CYP3A4	Inhibitor	—
CYP3A4	Substrate	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (10)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Butirol 7.5 Syrup	Syrup 7.5 mg/5 ml	100 ml	eastward drugstore	1.730
Joswe Solomax Syrup	Syrup 7.5 mg/5 ml	120 ml pack varies	Jordan Sweden Medical & Sterilization Co.	1.980
Dricod Syrup	Syrup 15 mg/10 ml	200 ml	PHILADELPHIA PHAEMACEUTICALS.COMP/JORDAN	2.400
Kofeez Syrup	Syrup 0.15 %	200 ml	Amman Pharmaceutical Industries Co	2.400
Rapicod	Solution 0.15 %	200 ml	Hayat Pharmaceutical Industries CO.PLC/JORDAN	2.400
Rapicod DS	Solution 0.3 %	145 ml pack varies	Hayat Pharmaceutical Industries CO.PLC/JORDAN	2.960
Joswe Solomax Syrup	Syrup 7.5 mg/5 ml	200 ml pack varies	Jordan Sweden Medical & Sterilization Co.	3.300
Sinecod drops	Oral Drops 5 mg/ml	20 ml	Sukhtian Group	3.650
Rapicod DS	Solution 0.3 %	200 ml pack varies	Hayat Pharmaceutical Industries CO.PLC/JORDAN	4.080
Sinecod Syrup	Syrup 1.5 mg/ml	200 ml	Sukhtian Group	5.210