Calcium Dobesilate

JFDA label: Dobesil-500mg capsules

Indications

Approved

• Varicose Veins — Varicose veins

Off-label

• Diabetes Mellitus, Type 2
• Infertility
• Menorrhagia
• Severe Acute Respiratory Syndrome

Chemistry & Properties

Formula	C12H10CaO10S2
Molecular weight	418.41 g/mol
IUPAC name	calcium bis(2,5-dihydroxybenzenesulfonate)
CAS	20123-80-2
PubChem CID	29963
InChIKey	QGNBTYAQAPLTMX-UHFFFAOYSA-L
logP	0.34
Polar surface area	94.83 Ų
H-bond acceptors / donors	4 / 3
Drug-likeness (QED)	0.44
Lipinski violations	0

SMILES

O=S(=O)([O-])c1cc(O)ccc1O.O=S(=O)([O-])c1cc(O)ccc1O.[Ca+2]

Biology & Pharmacokinetics

Pharmacokinetics predicted

Bioavailability	10.0%
Half-life	2.072 h
Volume of distribution	0.241 L/kg
Protein binding	73.2%
BBB penetrant	No

Enzyme interactions

Enzyme	Role	Detail
CYP2C9	Substrate	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (5)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Dobesil-500mg capsules	Capsule 500 mg	30 cap pack varies	AL-RAM PHARMA.INDUS.CO.LTD/JORDAN	10.000
Doxium Caps.	Capsule Monohydrate 500 mg	30 cap pack varies	Kurdi Drug Store	12.990
Doxium Caps.	Capsule Monohydrate 500 mg	60 cap pack varies	THE ARAB DRUG STORE P.S.C	22.890
Dobesil-500mg capsules	Capsule 500 mg	500 cap pack varies	AL-RAM PHARMA.INDUS.CO.LTD/JORDAN	145.000
Dobesil-500mg capsules	Capsule 500 mg	1000 cap pack varies	AL-RAM PHARMA.INDUS.CO.LTD/JORDAN	266.670