Cetylpyridinium

R02A - Throat preparations Small molecule Natural product

JFDA label: Septolete Total Lemon and Elder Flower 3 Mg/1 Mg Lozenges

Mechanism of Action

— Unknown

Contraindications

Source: Lexicomp

Hypersensitivity to cetylpyridinium or any component of the formulation Absolute

Adverse Reactions

Very Common >10%Common 1–10%Uncommon 0.1–1% Rare 0.01–0.1%Very Rare <0.01%Not Known

Other (3)

Not Known Dental discoloration · mouth irritation · tongue discoloration

Dosing

Source: Lexicomp

Antiseptic (OTC labeling): Oral: Swish 20 mL thoroughly between teeth for 30 seconds then spit; use twice daily; may be used before or after brushing; do not swallow.

Antiseptic (OTC labeling): Children ≥6 years: Refer to adult dosing.

Refer to adult dosing.

Warnings & Precautions

Source: Lexicomp

Accidental ingestion

If an amount greater than used for rinsing is swallowed, seek professional assistance or contact a poison control center immediately.

Self-medication (OTC use)

Stop use and consult a healthcare professional if symptoms or condition worsening or persists; if gingivitis, bleeding, or redness persists for more than 2 weeks; if gums are painful and swollen; if pus from the gum line, loose teeth, or increased spacing between the teeth occurs. Avoid contact with eyes.

Pregnancy & Lactation

Pregnancy

Cetylpyridinium chloride mouthwash (alcohol free) has been associated with a reduction in preterm births in pregnant women with periodontal disease (Jeffcoat, 2011).

Chemistry & Properties

Formula	C21H38N+
Molecular weight	304.54 g/mol
IUPAC name	1-hexadecylpyridin-1-ium
CAS	7773-52-6
PubChem CID	2683
InChIKey	`NEUSVAOJNUQRTM-UHFFFAOYSA-N`
logP	6.46 (XLogP 8.7)
Polar surface area	3.88 Å²
H-bond acceptors / donors	0 / 0
Drug-likeness (QED)	0.26
Lipinski violations	1

SMILES

CCCCCCCCCCCCCCCC[n+]1ccccc1

Biology & Pharmacokinetics

Pharmacokinetics predicted

Bioavailability	70.0%
Half-life	0.584 h
Volume of distribution	16.962 L/kg
Protein binding	99.4%
BBB penetrant	No

Enzyme interactions

Enzyme	Role	Detail
CYP2B6	Inhibitor	—
CYP2D6	Inhibitor	—
CYP2D6	Substrate	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (5)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Tasneen Gel	Gel 0.33 %, 0.1 %	15 g tube	Pharma International Company/ Jordan	0.940
Dentinox Teething Gel	Gel 0.33 %, 0.1 %	15 g tube	مستودع ادوية فزع	0.980
DAD TEETHING GEL	Gel 0.33 %, 0.1 %	15 g tube	Dar Al Dawa Development and Investment Co Ltd/Jordan	1.040
Septolete Total Lemon and Elder Flower 3 Mg/1 Mg Lozenges	Lozenge 1.050 mg, 3 mg	16 LOZ/1 BOX	Abu Sheikha Drug Store	6.900
Septolete Total Lemon and Honey 3 Mg/1 Mg Lozenges	Lozenge 1.050 mg, 3 mg	16 LOZ/1 BOX	Abu Sheikha Drug Store	6.900