Chorionic Gonadotrophin
G03G - Gonadotropins and other ovulation stimulants
ATC G03GA01
Protein
approved 1973
Parenteral
JFDA label: Gonacor VIAL
Mechanism of Action
Agonist of Lutropin-choriogonadotropic hormone receptor — Luteinizing hormone/Choriogonadotropin receptor agonist
| Target | Action | Gene / class |
|---|
| Lutropin-choriogonadotropic hormone receptor efficacy |
AGONIST |
LHCGR |
Indications
Off-label
- Anovulation
- Azoospermia
- Breast Neoplasms
- Hypogonadism
- Infertility
- Klinefelter Syndrome
- Polycystic Ovary Syndrome
- Pregnancy
Chemistry & Properties
| Formula | C11H19N3O6S |
|---|
| Molecular weight | 321.35 g/mol |
|---|
| IUPAC name | (2S)-2-amino-6-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-6-oxohexanoic acid |
|---|
| CAS | 9002-61-3 |
|---|
| PubChem CID | 4369448 |
|---|
| InChIKey | XFOOPZIJVVDYHI-BQBZGAKWSA-N |
|---|
| logP | -4.1 (XLogP -4.1) |
|---|
| Polar surface area | 160.0 Ų |
|---|
| H-bond acceptors / donors | 8 / 6 |
|---|
SMILES
C(CC(C(=O)O)N)CC(=O)NC(CS)C(=O)NCC(=O)OBiology & Pharmacokinetics
Pharmacokinetics predicted
| Bioavailability | 70.0% |
|---|
| Half-life | 0.932 h |
|---|
| Volume of distribution | 0.378 L/kg |
|---|
| Protein binding | 13.5% |
|---|
| BBB penetrant | No |
|---|
Enzyme interactions
| Enzyme | Role | Detail |
|---|
| CYP2D6 | Substrate |
— |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (1)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|
| Gonacor VIAL
|
Vial 5000 IU |
1+1 |
AL EIMAN DRUG STORE CO LLC |
4.770 |