Dapoxetine
G04B - Urologicals
ATC G04BX14
Small molecule
Natural product
JFDA label: Priligy 30 mg
Mechanism of Action
Inhibitor of Sodium-dependent serotonin transporter — Serotonin transporter inhibitor
| Target | Action | Gene / class |
|---|---|---|
| Sodium-dependent serotonin transporter efficacy | INHIBITOR | SLC6A4 |
Indications
Off-label
- Erectile Dysfunction
- Premature Ejaculation
- Sexual Dysfunction, Physiological
Adverse Reactions
Very Common >10%Common 1–10%Uncommon 0.1–1%
Rare 0.01–0.1%Very Rare <0.01%Not Known
Vascular disorders (1)
Uncommon Syncope / vasovagal (with postural change + alcohol)
Nervous system disorders (4)
Common Dizziness · Headache · Somnolence
Rare Serotonin syndrome (with serotonergic drugs)
Gastrointestinal disorders (2)
Very Common Nausea
Common Diarrhoea
Pregnancy & Lactation
Pregnancy
Chemistry & Properties
| Formula | C21H23NO |
|---|---|
| Molecular weight | 305.42 g/mol |
| IUPAC name | (1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine |
| CAS | 119356-77-3 |
| PubChem CID | 71353 |
| InChIKey | USRHYDPUVLEVMC-FQEVSTJZSA-N |
| logP | 4.91 (XLogP 5.1) |
| Polar surface area | 12.47 Ų |
| H-bond acceptors / donors | 2 / 0 |
| Drug-likeness (QED) | 0.64 |
| Lipinski violations | 0 |
SMILES
CN(C)[C@@H](CCOc1cccc2ccccc12)c1ccccc1Biology & Pharmacokinetics
Pharmacokinetics
| BBB penetrant | Yes |
|---|
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP1A2 | Inhibitor | — |
| CYP1A2 | Substrate | — |
| CYP2B6 | Inhibitor | — |
| CYP2B6 | Substrate | — |
| CYP2C19 | Inhibitor | — |
| CYP2C19 | Substrate | — |
| CYP2C9 | Inhibitor | — |
| CYP2C9 | Substrate | — |
| CYP2D6 | Inhibitor | — |
| CYP2D6 | Substrate | — |
| CYP3A4 | Substrate | — |
Receptor binding (top 1)
| Target | Action | Affinity |
|---|---|---|
| SERT (SLC6A4) | Inhibitor | pIC50 8.9 |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (41)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Depoo | Tablet 30 mg | 10 tab pack varies | Manar Drug Store | 1.700 |
| Depoo | Tablet 60 mg | 10 tab pack varies | Manar Drug Store | 2.710 |
| Elongo 30 | Tablet 30 mg | 1 tab pack varies | JORDAN SWEDEN MEDICAL&STERILE.CO(JOSWE)/JORDAN | 3.370 |
| Elongo 30 | Tablet 30 mg | 4 tab pack varies | JORDAN SWEDEN MEDICAL&STERILE.CO(JOSWE)/JORDAN | 3.370 |
| Elongo 30 | Tablet 30 mg | 20 tab pack varies | JORDAN SWEDEN MEDICAL&STERILE.CO(JOSWE)/JORDAN | 3.370 |
| Elongo 60 | Tablet 60 mg | 1 tab pack varies | JORDAN SWEDEN MEDICAL&STERILE.CO(JOSWE)/JORDAN | 3.370 |
| Depoo | Tablet 30 mg | 30 tab pack varies | Manar Drug Store | 4.790 |
| Extenda | Tablet 30 mg | 1 tab pack varies | Itqan Pharmaceutical Industries/Jordan | 5.040 |
| Hawai 30 | Tablet 30 mg | 1 tab pack varies | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 5.060 |
| DABET | Tablet 30 mg | 1 tab pack varies | Hikma Pharmaceuticals Co.Ltd/Jordan | 5.280 |
| Extenda | Tablet 60 mg | 1 tab pack varies | Itqan Pharmaceutical Industries/Jordan | 6.550 |
| Hawai 60 | Tablet 60 mg | 1 tab pack varies | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 6.570 |
| DABET | Tablet 60 mg | 1 tab pack varies | Hikma Pharmaceuticals Co.Ltd/Jordan | 6.860 |
| Depoo | Tablet 60 mg | 30 tab pack varies | Manar Drug Store | 7.640 |
| D-Late 30mg F.C Tablet | Film-Coated Tablet 30 mg | 3 tab | Savvy Pharma | 8.650 |
| Endura 30 mg F.C Tablet | Film-Coated Tablet 30 mg | 3 tab pack varies | Pharma International Company/ Jordan | 11.540 |
| Priligy | Tablet (as Hcl ) 30 mg | 3 tab | ORIENT DRUG STORE CO | 11.720 |
| Priligy | Tablet (as Hcl) 60 mg | 3 tab | ORIENT DRUG STORE CO | 11.720 |
| Dapo 60mg film coated tablet | Film-Coated Tablet 60 mg | 4 tab | Khoury Drug Store | 11.810 |
| D-Late 60mg F.C Tablet | Film-Coated Tablet 60 mg | 3 tab | Savvy Pharma | 11.840 |
| Elongo 60 | Tablet 60 mg | 4 tab pack varies | JORDAN SWEDEN MEDICAL&STERILE.CO(JOSWE)/JORDAN | 12.500 |
| Extenda | Tablet 30 mg | 3 tab pack varies | Itqan Pharmaceutical Industries/Jordan | 14.270 |
| Hawai 30 | Tablet 30 mg | 3 tab pack varies | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 14.270 |
| Endura 60mg F.C Tab | Film-Coated Tablet (as HCl) 60 mg | 3 tab pack varies | Pharma International Company/ Jordan | 14.430 |
| DABET | Tablet 30 mg | 3 tab pack varies | Hikma Pharmaceuticals Co.Ltd/Jordan | 15.820 |
| Depojoy | Tablet 30 mg | 6 tab | Ibn Rushd Drug Store | 18.380 |
| Depojoy | Tablet 60 mg | 6 tab | Ibn Rushd Drug Store | 18.380 |
| Extenda | Tablet 60 mg | 3 tab pack varies | Itqan Pharmaceutical Industries/Jordan | 18.530 |
| Hawai 60 | Tablet 60 mg | 3 tab pack varies | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 18.530 |
| tapomen | Tablet 33.58 mg | 3 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 18.720 |
| Extenda | Tablet 30 mg | 10 tab pack varies | Itqan Pharmaceutical Industries/Jordan | 19.230 |
| DABET | Tablet 60 mg | 3 tab pack varies | Hikma Pharmaceuticals Co.Ltd/Jordan | 20.750 |
| Tapomen | Tablet 60 mg | 3 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 21.290 |
| Endura 30 mg F.C Tablet | Film-Coated Tablet 30 mg | 6 tab pack varies | Pharma International Company/ Jordan | 27.090 |
| Extenda | Tablet 60 mg | 10 tab pack varies | Itqan Pharmaceutical Industries/Jordan | 28.850 |
| Endura 60mg F.C Tab | Film-Coated Tablet (as HCl) 60 mg | 6 tab pack varies | Pharma International Company/ Jordan | 35.220 |
| Elongo 60 | Tablet 60 mg | 20 tab pack varies | JORDAN SWEDEN MEDICAL&STERILE.CO(JOSWE)/JORDAN | 57.290 |
| Hawai 30 | Tablet 30 mg | 30 tab pack varies | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 75.000 |
| Hawai 30 | Tablet 30 mg | 36 tab pack varies | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 80.000 |
| Hawai 60 | Tablet 60 mg | 30 tab pack varies | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 85.000 |
| Hawai 60 | Tablet 60 mg | 36 tab pack varies | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 90.000 |