Dexketoprofen
M01A - NSAIDs and antirheumatic products, non-steroids
ATC M01AE17
Small molecule
approved 1994
Oral
Natural product
🧬 Cross-allergy: NSAIDs
JFDA label: Ketesse
Mechanism of Action
Inhibitor of Cyclooxygenase — Cyclooxygenase inhibitor
| Target | Action | Gene / class |
|---|---|---|
| Cyclooxygenase efficacy | INHIBITOR |
Indications
Approved
- Arthralgia — Arthralgia
- Myalgia — Myalgia
- Rheumatic Diseases — rheumatic disease
Off-label
- Low Back Pain
- Pain
- Wounds and Injuries
Pregnancy & Lactation
Pregnancy
Chemistry & Properties
| Formula | C16H14O3 |
|---|---|
| Molecular weight | 254.29 g/mol |
| IUPAC name | (2S)-2-(3-benzoylphenyl)propanoic acid |
| CAS | 22161-81-5 |
| PubChem CID | 667550 |
| InChIKey | DKYWVDODHFEZIM-NSHDSACASA-N |
| logP | 3.11 (XLogP 3.1) |
| Polar surface area | 54.37 Ų |
| H-bond acceptors / donors | 2 / 1 |
| Drug-likeness (QED) | 0.85 |
| Lipinski violations | 0 |
SMILES
C[C@H](C(=O)O)c1cccc(C(=O)c2ccccc2)c1Biology & Pharmacokinetics
Pharmacokinetics
| BBB penetrant | Yes |
|---|
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (4)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Ketesse | Tablet 25 mg | 20 tab | ORIENT DRUG STORE CO | 3.030 |
| Ketesse 25mg Granules For Oral Solution | Solution 25 mg | 20 sachet | ORIENT DRUG STORE CO | 3.360 |
| Ketesse contains ethanol | Ampoule 50 mg/2 ml | 5 amp | ORIENT DRUG STORE CO | 3.900 |
| Skudexa | Tablet 75 mg, 25 mg | 20 tab | ORIENT DRUG STORE CO | 5.790 |