Dexpanthenol

D03A - Enzymes ATC D03AX03 Small molecule approved 1985 Parenteral Natural product

JFDA label: Panthophil Topical Solution

Mechanism of Action

A pantothenic acid B vitamin analog that is converted to coenzyme A internally; coenzyme A is essential to normal fatty acid synthesis, amino acid synthesis and acetylation of choline in the production of the neurotransmitter, acetylcholine

Indications

Approved

Injection
Topical

Contraindications

Source: Lexicomp

There are no contraindications listed in the manufacturer's labeling Absolute

Adverse Reactions

Very Common >10%Common 1–10%Uncommon 0.1–1% Rare 0.01–0.1%Very Rare <0.01%Not Known

Cardiac disorders (1)

Not Known Decreased blood pressure (slight)

Nervous system disorders (2)

Not Known Agitation · paresthesia

Immune system disorders (1)

Not Known Hypersensitivity reaction

Gastrointestinal disorders (3)

Not Known Diarrhea · increased peristalsis · vomiting

Skin and subcutaneous tissue disorders (4)

Not Known Dermatitis · pruritus · skin irritation · urticaria

Respiratory, thoracic and mediastinal disorders (1)

Not Known Dyspnea

Dosing

Source: Lexicomp

Note: Dexpanthenol injection has been discontinued in the US for more than 1 year. Minor dermatoses: Topical: Apply to affected area once or twice daily Prevention of postoperative paralytic ileus: IM: 250 or 500 mg, repeat in 2 hours, and then every 6 hours until danger of paralytic ileus passes. Note: If needed, 500 mg (2 mL) dose may also be given IV. Treatment of paralytic ileus: IM: 500 mg, repeat in 2 hours, and then every 6 hours as needed. Note: If needed, 500 mg (2 mL) dose may also be given IV.

Minor dermatoses: Topical: Children and Adolescents: Refer to adult dosing.

Refer to adult dosing.

There are no dosage adjustments provided in the manufacturer's labeling.

Warnings & Precautions

Source: Lexicomp

Hypersensitivity reaction

Discontinue if any sign of hypersensitivity reaction occurs. Other warnings/precautions:

Appropriate use

Management of adynamic ileus should include correction of fluid and electrolyte imbalance (especially hypokalemia), anemia, hypoproteinemia, treatment of infection, and the avoidance of drugs which decrease GI motility and decompression of the GI tract when considerably distended by nasogastric suction or use of a long intestinal tube. If ileus is a secondary consequence of mechanical obstruction, primary attention should be directed to the obstruction.

Pregnancy & Lactation

Pregnancy

FDA category C

Animal reproduction studies have not been conducted.

Lactation

Lactating women should follow the U.S. Recommended Daily Allowances for their condition since their vitamin requirement may exceed those of nonlactating women. It is not known if dexpanthenol is excreted in human milk. The manufacturer recommends that caution be exercised when administering dexpanthenol to nursing women.

Chemistry & Properties

Formula	C9H19NO4
Molecular weight	205.25 g/mol
IUPAC name	(2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
CAS	81-13-0
PubChem CID	131204
InChIKey	`SNPLKNRPJHDVJA-ZETCQYMHSA-N`
logP	-1.14 (XLogP -0.9)
Polar surface area	89.79 Å²
H-bond acceptors / donors	4 / 4
Drug-likeness (QED)	0.41
Lipinski violations	0

SMILES

CC(C)(CO)[C@@H](O)C(=O)NCCCO

Biology & Pharmacokinetics

Pharmacokinetics

BBB penetrant	No

Enzyme interactions

Enzyme	Role	Detail
CYP2C19	Substrate	—
CYP3A4	Substrate	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (6)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Pantol Oint	Ointment 5 %	30gm	Pharma International Company/ Jordan	1.440
Panthophil Plus Cream	Cream 50 mg/g, 5 mg/g	30 g tube	PHILADELPHIA PHAEMACEUTICALS.COMP/JORDAN	1.560
Panthophil Topical Solution	Solution 5 %	50 ml pack varies	PHILADELPHIA PHAEMACEUTICALS.COMP/JORDAN	1.750
Panthophil Cream	Cream 5 %	30 g tube pack varies	PHILADELPHIA PHAEMACEUTICALS.COMP/JORDAN	1.800
Bepanthen Cream	Cream 5 %	30 g tube	The Jordan Drugstore Co	2.230
BEPANTHEN OINTMENT	Ointment 0.05 g/1 g	30 g tube	The Jordan Drugstore Co	2.650