Diacerein

M01A - NSAIDs and antirheumatic products, non-steroids ATC M01AX21 Small molecule Natural product

JFDA label: ART-50 50mg

Mechanism of Action

— Unknown

Indications

Approved

Rheumatic Diseases — rheumatic disease

Off-label

Arthritis, Rheumatoid
Diabetes Mellitus, Type 2
Epidermolysis Bullosa
Epidermolysis Bullosa Simplex
Gout
Osteoarthritis
Osteoarthritis, Hip
Osteoarthritis, Knee
Pemphigoid, Bullous
Severe Acute Respiratory Syndrome
Thrombocytopenia

Pregnancy & Lactation

Pregnancy

Chemistry & Properties

Formula	C19H12O8
Molecular weight	368.3 g/mol
IUPAC name	4,5-diacetyloxy-9,10-dioxoanthracene-2-carboxylic acid
CAS	13739-02-1
PubChem CID	26248
InChIKey	`TYNLGDBUJLVSMA-UHFFFAOYSA-N`
logP	2.01 (XLogP 1.9)
Polar surface area	124.04 Å²
H-bond acceptors / donors	7 / 1
Drug-likeness (QED)	0.55
Lipinski violations	0

SMILES

CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O

Biology & Pharmacokinetics

Pharmacokinetics

BBB penetrant	No

Enzyme interactions

Enzyme	Role	Detail
CYP2C8	Inhibitor	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)MRP2 (Inhibitor)MRP3 (Inhibitor)MRP4 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)OATP2B1 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (1)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
ART-50	Tablet 50 mg	30 tab	Pharma International Company/ Jordan	9.700