Diclofenac Deanol
M01A - NSAIDs and antirheumatic products, non-steroids
ATC M02AA15
JFDA label: Tratul Gel
Chemistry & Properties
| Formula | C18H22Cl2N2O3 |
|---|
| Molecular weight | 385.3 g/mol |
|---|
| IUPAC name | 2-[2-(2,6-dichloroanilino)phenyl]acetic acid;2-(dimethylamino)ethanol |
|---|
| CAS | 81811-14-5 |
|---|
| PubChem CID | 9908124 |
|---|
| InChIKey | AINBLHPPOHIAEC-UHFFFAOYSA-N |
|---|
| Polar surface area | 72.8 Ų |
|---|
| H-bond acceptors / donors | 5 / 3 |
|---|
SMILES
CN(C)CCO.C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)ClBiology & Pharmacokinetics
Pharmacokinetics predicted
| Bioavailability | 10.0% |
|---|
| Half-life | 1.64 h |
|---|
| Volume of distribution | 0.18 L/kg |
|---|
| Protein binding | 99.2% |
|---|
| BBB penetrant | Yes |
|---|
Enzyme interactions
| Enzyme | Role | Detail |
|---|
| CYP1A2 | Substrate |
— |
| CYP2B6 | Substrate |
— |
| CYP2C19 | Substrate |
— |
| CYP2C9 | Inhibitor |
— |
| CYP2C9 | Substrate |
— |
| CYP3A4 | Substrate |
— |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (5)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|
| Tratul Supp
|
Suppository 60 mg |
6 supp |
G.L PHARMA GMBH/LANNACH/AUSTRIA |
1.910 |
| Tratul Gel
|
Gel 1.21 % |
45 g tube |
Hayat Pharmaceutical Industries CO.PLC/JORDAN |
2.150 |
| Tratul Amp
|
Ampoule 90 mg/3 ml |
5 amp pack varies |
Kurdi Drug Store |
3.920 |
| Tratul Supp
|
Suppository 120 mg |
6 supp |
G.L PHARMA GMBH/LANNACH/AUSTRIA |
4.020 |
| Tratul Amp
|
Ampoule 90 mg/3 ml |
50 amp pack varies |
Kurdi Drug Store |
35.270 |