Dimetindene

JFDA label: Vibrocil Drops

Mechanism of Action

Antagonist of Histamine H1 receptor — Histamine H1 receptor antagonist

Target	Action	Gene / class
Histamine H1 receptor efficacy	ANTAGONIST	HRH1

Indications

Off-label

• Hypersensitivity
• Pruritus

Chemistry & Properties

Formula	C20H24N2
Molecular weight	292.43 g/mol
IUPAC name	N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine
CAS	5636-83-9
PubChem CID	21855
InChIKey	MVMQESMQSYOVGV-UHFFFAOYSA-N
logP	4.15 (XLogP 2.7)
Polar surface area	16.13 Ų
H-bond acceptors / donors	2 / 0
Drug-likeness (QED)	0.82
Lipinski violations	0

SMILES

CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1

Biology & Pharmacokinetics

Pharmacokinetics

BBB penetrant	Yes

Enzyme interactions

Enzyme	Role	Detail
CYP2B6	Inhibitor	—
CYP2B6	Substrate	—
CYP2C19	Inhibitor	—
CYP2C19	Substrate	—
CYP2C8	Inhibitor	—
CYP2C9	Inhibitor	—
CYP3A4	Substrate	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (18)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Fencil Skin Gel	Gel 0.1 %	15 g tube	Amman Pharmaceutical Indusries	0.670
Pediafast Gel	Gel 0.1 %WW	30 GM	JERASH PHARMACEUTICALS LTD.CO/JORDAN	1.360
Pediafast Syrup	Syrup 0.01 g/100 ml	60 ml pack varies	JERASH PHARMACEUTICALS LTD.CO/JORDAN	1.400
FENISTIL TAB	Tablet 1 mg	20 tab	Nabulsi Drug Store	1.550
Fenistil gel	Gel 1 mg/g	30 g tube	Sukhtian Group	1.600
Vibrocil Drops	Oral Drops 0.25 mg/ml, 2.5 mg/ml	15 ml	Sukhtian Group	1.640
Alergin Drops	Oral Drops 1 mg/ml	20 ml pack varies	Jordan Sweden Medical & Sterilization Co.	1.720
Fencil Oral Drops	Oral Drops 0.1 %	30 ml	Amman Pharmaceutical Industries Co	1.790
VIBROCIL GEL	Gel 0.25 mg/g, 2.5 mg/g	12 g tube	Sukhtian Group	1.830
Vapicil	Solution 0.025 %, 0.25 %	15 ml	Amman Pharmaceutical Indusries	1.980
FENISTIL DROPS	Oral Drops 1 mg/ml	20 ml	Sukhtian Group	2.150
Pediafast Drops	Oral Drops 0.1 g/100 ml	25 ml pack varies	JERASH PHARMACEUTICALS LTD.CO/JORDAN	2.150
VIBROCIL MD SPRAY	Spray 0.25 mg/ml, 2.5 mg/ml	15 ml	Sukhtian Group	2.470
Alergin Drops	Oral Drops 1 mg/ml	30 ml pack varies	Jordan Sweden Medical & Sterilization Co.	2.580
FENISTIL Prolonged Release Cap	Capsule 4 mg	10 cap	Nabulsi Drug Store	2.580
Pediafast Drops	Oral Drops 0.1 g/100 ml	30 ml pack varies	JERASH PHARMACEUTICALS LTD.CO/JORDAN	2.580
Pediafast Syrup	Syrup 0.01 g/100 ml	100 ml pack varies	JERASH PHARMACEUTICALS LTD.CO/JORDAN	2.800
Pediafast Syrup	Syrup 0.01 g/100 ml	120 ml pack varies	JERASH PHARMACEUTICALS LTD.CO/JORDAN	3.360