Diosmectite

JFDA label: Smecta 3g Orange-Vanilla

Indications

Off-label

• Breast Neoplasms
• Diarrhea

Chemistry & Properties

Formula	Al2H2O12Si4
Molecular weight	360.31 g/mol
IUPAC name	dialuminum;tetrakis(dioxosilane);tris(oxygen(2-));hydrate
CAS	1318-93-0
PubChem CID	71586775
InChIKey	GUJOJGAPFQRJSV-UHFFFAOYSA-N
Polar surface area	141.0 Ų
H-bond acceptors / donors	12 / 1

SMILES

O.[O-2].[O-2].[O-2].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.[Al+3].[Al+3]

Biology & Pharmacokinetics

Pharmacokinetics predicted

Bioavailability	10.0%
Half-life	1.87 h
Volume of distribution	0.612 L/kg
Protein binding	0.4%
BBB penetrant	No

Enzyme interactions

Enzyme	Role	Detail
CYP2C19	Substrate	—
CYP2C9	Substrate	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (1)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Smecta 3g Orange-Vanilla	Sachet 3 g/3.76 g	30 sachet	Abu Sharef Medical Stores	3.600