Diosmin

C05C - Capillary stabilizing agents ATC C05CA03 Small molecule Natural product Withdrawn Black-box warning

JFDA label: Diovenor Tab

⚠ Black-Box Warning

Drug Withdrawn from Market — ChEMBL drug_warning (Withdrawn) | Spain | unfavourable risk-benefit profile

Mechanism of Action

— Unknown

Indications

Approved

Cardiovascular Diseases — cardiovascular disease

Off-label

Arthritis, Rheumatoid
Colitis, Ulcerative
Infertility
Non-alcoholic Fatty Liver Disease
Peptic Ulcer
Venous Insufficiency

Contraindications

Source: openFDA

Do not use if you have a known allergy to any of the ingredients in Bruselix™ Bruising Tablets , including Arnica Montana or pineapple (Bromelain). Avoid use if you have an allergy to citrus or bioflavonoid components. Absolute

Dosing

Source: openFDA

Take one (1) Bruselix™ Bruising Tablets daily, or as directed by a licensed healthcare practitioner. Do not exceed recommended dose.

Warnings & Precautions

Source: openFDA

Warnings & Precautions

Arnica: May cause allergic reactions in sensitive individuals, especially if there is a history of ragweed allergies. Bromelain: May increase the risk of bleeding in individuals taking anticoagulants or antiplatelet medications. Discontinue use two weeks before surgery. Zinc and Vitamin C: Use cautiously in individuals with kidney disease or those prone to kidney stones. If you experience an allergic reaction or prolonged bleeding, discontinue use and seek medical attention immediately. For use on the order of a licensed healthcare practitioner. Call your doctor about side effects. To report side effects, call PureTek Corporation at 1-877-921-7873.

Chemistry & Properties

Formula	C28H32O15
Molecular weight	608.55 g/mol
IUPAC name	5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
CAS	520-27-4
PubChem CID	5281613
InChIKey	`GZSOSUNBTXMUFQ-YFAPSIMESA-N`
logP	-1.09 (XLogP -0.8)
Polar surface area	238.2 Å²
H-bond acceptors / donors	15 / 8
Drug-likeness (QED)	0.16
Lipinski violations	3

SMILES

COc1ccc(-c2cc(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3o2)cc1O

Biology & Pharmacokinetics

Pharmacokinetics

BBB penetrant	No

Enzyme interactions

Enzyme	Role	Detail
CYP2C8	Inhibitor	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MDR1 (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (2)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Diosper Tab	Tablet 450 mg, 50 mg	30 tab	AL Rahma Drug Store	3.140
Diovenor Tab	Tablet 600 mg	30 tab	Quality Drug Store	9.100