Dithranol
D05A - Antipsoriatics for topical use
ATC D05AC51
Small molecule
Natural product
JFDA label: psorianol oint
Mechanism of Action
— Unknown
Indications
Approved
- Psoriasis — psoriasis
Pregnancy & Lactation
Lactation
No Data
Hale L3
Topical anthralin has not been studied during breastfeeding.
Chemistry & Properties
| Formula | C14H10O3 |
|---|---|
| Molecular weight | 226.23 g/mol |
| IUPAC name | 1,8-dihydroxy-10H-anthracen-9-one |
| CAS | 1143-38-0 |
| PubChem CID | 2202 |
| InChIKey | NUZWLKWWNNJHPT-UHFFFAOYSA-N |
| logP | 2.23 (XLogP 3.2) |
| Polar surface area | 57.53 Ų |
| H-bond acceptors / donors | 3 / 2 |
| Drug-likeness (QED) | 0.62 |
| Lipinski violations | 0 |
SMILES
O=C1c2c(O)cccc2Cc2cccc(O)c21Biology & Pharmacokinetics
Pharmacokinetics
| BBB penetrant | No |
|---|
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP1A2 | Inhibitor | — |
| CYP1A2 | Substrate | — |
| CYP2B6 | Inhibitor | — |
| CYP2C8 | Inhibitor | — |
| CYP2C9 | Substrate | — |
| CYP2D6 | Inhibitor | — |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (1)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| psorianol oint | Ointment 0.1 %, 1 % | 30 g tube | MIDDLE EAST PHARMA&CHEMICAL IND/JORDAN | 2.880 |