Dydrogesterone
G03D - Progestogens
ATC G03DB01
Small molecule
approved 1982
Oral
Natural product
JFDA label: Duphaston Tab
Mechanism of Action
Agonist of Progesterone receptor — Progesterone receptor agonist
| Target | Action | Gene / class |
|---|---|---|
| Progesterone receptor efficacy | AGONIST | PGR |
Indications
Off-label
- Abortion, Habitual
- Infertility
- Infertility, Female
- Menopause
- Pregnancy
- Premature Birth
Pregnancy & Lactation
Pregnancy
Chemistry & Properties
| Formula | C21H28O2 |
|---|---|
| Molecular weight | 312.45 g/mol |
| IUPAC name | (8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one |
| CAS | 152-62-5 |
| PubChem CID | 9051 |
| InChIKey | JGMOKGBVKVMRFX-HQZYFCCVSA-N |
| logP | 4.5 (XLogP 3.8) |
| Polar surface area | 34.14 Ų |
| H-bond acceptors / donors | 2 / 0 |
| Drug-likeness (QED) | 0.71 |
| Lipinski violations | 0 |
SMILES
CC(=O)[C@H]1CC[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@@]4(C)[C@@H]3CC[C@]12CBiology & Pharmacokinetics
Pharmacokinetics predicted
| Bioavailability | 70.0% |
|---|---|
| Half-life | 0.572 h |
| Volume of distribution | 1.759 L/kg |
| Protein binding | 93.0% |
| BBB penetrant | Yes |
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP1A2 | Substrate | — |
| CYP2B6 | Inhibitor | — |
| CYP2C19 | Inhibitor | — |
| CYP2C19 | Substrate | — |
| CYP2C8 | Inhibitor | — |
| CYP2C9 | Substrate | — |
| CYP2D6 | Substrate | — |
| CYP3A4 | Inhibitor | — |
| CYP3A4 | Substrate | — |
Receptor binding (top 1)
| Target | Action | Affinity |
|---|---|---|
| Progesterone receptor (PGR) | Agonist | pKi 6.9 |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (4)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Motaston | Tablet 10 mg | 20 tab | Al-Motakadema Pharmaceutical LTD. | 4.380 |
| Femoston Tab | Tablet 2 mg, 10 mg | 3X28 | Khraim Drug Store | 17.140 |
| Femoston conti | Tablet 1 mg, 5 mg | 28 tab | Khraim Drug Store | 19.050 |
| Duphaston Tab | Tablet 10 mg | 20 tab | Abu Sheikha Drug Store | — |