Eperisone
M03B - Muscle relaxants, centrally acting agents
ATC M03BX09
Small molecule
Natural product
JFDA label: Myonal Tab
Indications
Off-label
Chemistry & Properties
| Formula | C17H25NO |
|---|
| Molecular weight | 259.39 g/mol |
|---|
| IUPAC name | 1-(4-ethylphenyl)-2-methyl-3-piperidin-1-ylpropan-1-one |
|---|
| CAS | 64840-90-0 |
|---|
| PubChem CID | 3236 |
|---|
| InChIKey | SQUNAWUMZGQQJD-UHFFFAOYSA-N |
|---|
| logP | 3.55 (XLogP 3.8) |
|---|
| Polar surface area | 20.31 Ų |
|---|
| H-bond acceptors / donors | 2 / 0 |
|---|
| Drug-likeness (QED) | 0.75 |
|---|
| Lipinski violations | 0 |
|---|
SMILES
CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1Biology & Pharmacokinetics
Pharmacokinetics predicted
| Bioavailability | 10.0% |
|---|
| Half-life | 1.047 h |
|---|
| Volume of distribution | 5.507 L/kg |
|---|
| Protein binding | 85.0% |
|---|
| BBB penetrant | Yes |
|---|
Enzyme interactions
| Enzyme | Role | Detail |
|---|
| CYP2C19 | Substrate |
— |
| CYP2D6 | Inhibitor |
IC₅₀ 4.903400000000001 µM |
| CYP3A4 | Substrate |
— |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (2)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|
| Myonal Tab
|
Tablet 50 mg |
30 tab pack varies |
AL-TAQADDOM PHARMACEUTICAL INDUSTRIES/JORDAN |
5.870 |
| Myonal Tab
|
Tablet 50 mg |
100 tab pack varies |
AL-TAQADDOM PHARMACEUTICAL INDUSTRIES/JORDAN |
18.390 |