Erythropoietin Beta

JFDA label: Recormon PFS

Chemistry & Properties

Formula	C42H73NO16
Molecular weight	848.0 g/mol
IUPAC name	(4R,5S,6S,7R,9R,10R,11E,13E,16R)-10-[(2R,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-6-[(2S,3R,4R,5S,6R)-5-[(2R,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-7-(2-hydroxyethyl)-5-methoxy-9,16-dimethyl-1-oxacyclohexadeca-11,13-dien-2-one
CAS	113427-24-0
PubChem CID	92043599
InChIKey	CJKGNDLRMLFWEX-IUJNAFBCSA-N
logP	0.8 (XLogP 0.8)
Polar surface area	236.0 Ų
H-bond acceptors / donors	17 / 7

SMILES

CC1CC=CC=CC(C(CC(C(C(C(CC(=O)O1)O)OC)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CCO)C)OC4CC(C(C(O4)C)O)(C)O

Biology & Pharmacokinetics

Pharmacokinetics predicted

Bioavailability	70.0%
Half-life	5.786 h
Volume of distribution	0.784 L/kg
Protein binding	49.3%
BBB penetrant	No

Enzyme interactions

Enzyme	Role	Detail
CYP2C19	Substrate	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (5)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
RECORMON VIAL	Vial 5000 IU	5 +5 SOLV.	Shawi & Rushedat Drug Store	—
Recormon PFS	Pre-filled Syringe 5000 IU/0.3 ml	6	Shawi & Rushedat Drug Store	—
Recormon PFS	Pre-filled Syringe 2000 IU/0.3 ml	6 PFS	Shawi & Rushedat Drug Store	—
Recormon PFS	Pre-filled Syringe 6000 IU/0.3 ml	6	Shawi & Rushedat Drug Store	—
Recormon PFS	Pre-filled Syringe 30000 IU/0.6 ml	4 PFS	Shawi & Rushedat Drug Store	—