Etamsylate
B02B - Vitamin K and other haemostatics
ATC B02BX01
Small molecule
JFDA label: Dicynone Amp
Indications
Approved
Pregnancy & Lactation
Chemistry & Properties
| Formula | C10H17NO5S |
|---|
| Molecular weight | 263.31 g/mol |
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| IUPAC name | 2,5-dihydroxybenzenesulfonic acid;N-ethylethanamine |
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| CAS | 2624-44-4 |
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| PubChem CID | 17506 |
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| InChIKey | HBGOLJKPSFNJSD-UHFFFAOYSA-N |
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| logP | 0.34 |
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| Polar surface area | 94.83 Ų |
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| H-bond acceptors / donors | 4 / 3 |
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| Drug-likeness (QED) | 0.44 |
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| Lipinski violations | 0 |
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SMILES
CCNCC.O=S(=O)(O)c1cc(O)ccc1OBiology & Pharmacokinetics
Pharmacokinetics predicted
| Bioavailability | 35.0% |
|---|
| Half-life | 1.791 h |
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| Volume of distribution | 0.107 L/kg |
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| Protein binding | 68.7% |
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| BBB penetrant | No |
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Enzyme interactions
| Enzyme | Role | Detail |
|---|
| CYP2C9 | Substrate |
— |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (2)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|
| Dicynone Amp
|
Ampoule 250 mg/2 ml |
4 amp |
Kurdi Drug Store |
5.470 |
| Dicynone Tablets
|
Tablet 500 mg |
20 tab |
Kurdi Drug Store |
16.280 |