Etifoxine
N05B - Anxiolytics
ATC N05BX03
Small molecule
Natural product
JFDA label: Stresam 50mg
Mechanism of Action
Antagonist of GABA-A receptor; anion channel — GABA-A receptor; anion channel antagonist
| Target | Action | Gene / class |
|---|
| GABA-A receptor; anion channel efficacy |
ANTAGONIST |
|
Indications
Off-label
Chemistry & Properties
| Formula | C17H17ClN2O |
|---|
| Molecular weight | 300.79 g/mol |
|---|
| IUPAC name | 6-chloro-N-ethyl-4-methyl-4-phenyl-1H-3,1-benzoxazin-2-imine |
|---|
| CAS | 21715-46-8 |
|---|
| PubChem CID | 135413553 |
|---|
| InChIKey | IBYCYJFUEJQSMK-UHFFFAOYSA-N |
|---|
| logP | 4.23 (XLogP 4.1) |
|---|
| Polar surface area | 33.62 Ų |
|---|
| H-bond acceptors / donors | 3 / 1 |
|---|
| Drug-likeness (QED) | 0.90 |
|---|
| Lipinski violations | 0 |
|---|
SMILES
CCNC1=Nc2ccc(Cl)cc2C(C)(c2ccccc2)O1Biology & Pharmacokinetics
Pharmacokinetics
Enzyme interactions
| Enzyme | Role | Detail |
|---|
| CYP1A2 | Inhibitor |
— |
| CYP2B6 | Inhibitor |
— |
| CYP2C19 | Inhibitor |
— |
| CYP2C19 | Substrate |
— |
| CYP2C8 | Inhibitor |
— |
| CYP2C9 | Inhibitor |
— |
| CYP2D6 | Inhibitor |
— |
| CYP3A4 | Inhibitor |
— |
| CYP3A4 | Substrate |
— |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (1)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|
| Stresam
|
Tablet 50 mg |
60 tab |
THE ARAB DRUG STORE P.S.C |
4.230 |