Etoricoxib
M01A - NSAIDs and antirheumatic products, non-steroids
ATC M01AH05
Small molecule
Oral
Natural product
🧬 Cross-allergy: NSAIDs
JFDA label: Orotix 120mg Tablet
Mechanism of Action
Inhibitor of Prostaglandin G/H synthase 2 — Cyclooxygenase-2 inhibitor
| Target | Action | Gene / class |
|---|---|---|
| Prostaglandin G/H synthase 2 efficacy | INHIBITOR | PTGS2 |
Indications
Approved
- Rheumatic Diseases — rheumatic disease
Off-label
- Arthritis, Rheumatoid
- Bone Neoplasms
- Dysmenorrhea
- HIV Infections
- Low Back Pain
- Osteoarthritis
- Osteoarthritis, Knee
- Pain
- Prostatic Neoplasms, Castration-Resistant
- Spondylitis, Ankylosing
- Toothache
- Wounds and Injuries
Class profile
| cox1_IC50_uM | 116.0 |
|---|---|
| cox2_IC50_uM | 1.1 |
| cox2_selectivity | 105.45454545454544 |
| inhibitionType | reversible |
| preferentialCOX2 | 1 |
| selectiveCOX2 | 1 |
| plateletEffect | 0 |
| source | Warner1999/Vane1996/ChEMBL |
Adverse Reactions
Very Common >10%Common 1–10%Uncommon 0.1–1%
Rare 0.01–0.1%Very Rare <0.01%Not Known
Cardiac disorders (1)
Uncommon Cardiovascular thrombotic events (MI, stroke)
Vascular disorders (1)
Common Hypertension
Nervous system disorders (2)
Common Dizziness · Headache
Hepatobiliary disorders (1)
Common Elevated liver enzymes
Renal and urinary disorders (1)
Rare Acute kidney injury
Gastrointestinal disorders (1)
Common Dyspepsia
General disorders and administration site conditions (1)
Common Oedema / fluid retention
Pregnancy & Lactation
Pregnancy
Lactation
Caution
Hale L3
Some guidelines recommend avoiding etoricoxib because of a lack of data during breastfeeding. An alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Monitoring
| Efficacy | Pain and inflammation control (VAS/NRS scores, joint mobility, functional status); minimum effective dose |
|---|---|
| Toxicity | Blood pressure (raises BP, antagonises antihypertensives); renal function (SCr, eGFR — especially in elderly, heart failure, CKD, dehydrated); Hb/faecal occult blood (GI bleeding); LFTs; oedema |
| Clinical pearl | Use the lowest effective dose for the shortest duration. Consider co-prescribing a proton pump inhibitor if GI risk factors present. COX-2 selective agents reduce GI but not CV risk. |
| Counseling | Take with food or milk to reduce GI upset. Report black stools, blood in urine, or significant ankle swelling. Monitor blood pressure regularly if hypertensive. |
Chemistry & Properties
| Formula | C18H15ClN2O2S |
|---|---|
| Molecular weight | 358.85 g/mol |
| IUPAC name | 5-chloro-2-(6-methyl-3-pyridinyl)-3-(4-methylsulfonylphenyl)pyridine |
| CAS | 202409-33-4 |
| PubChem CID | 123619 |
| InChIKey | MNJVRJDLRVPLFE-UHFFFAOYSA-N |
| logP | 4.18 (XLogP 3.3) |
| Polar surface area | 59.92 Ų |
| H-bond acceptors / donors | 4 / 0 |
| Drug-likeness (QED) | 0.70 |
| Lipinski violations | 0 |
SMILES
Cc1ccc(-c2ncc(Cl)cc2-c2ccc(S(C)(=O)=O)cc2)cn1Biology & Pharmacokinetics
Pharmacokinetics
| BBB penetrant | No |
|---|
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP1A2 | Inhibitor | — |
| CYP1A2 | Substrate | — |
| CYP2C8 | Inhibitor | — |
| CYP2C9 | Substrate | — |
| CYP2D6 | Substrate | — |
| CYP3A4 | Substrate | — |
Receptor binding (top 3)
| Target | Action | Affinity |
|---|---|---|
| Prostaglandin E2 (PTGER2) | Binding | pKi 7.1 |
| COX-2 (PTGS2) | Inhibitor | pIC50 6.0 |
| COX-2 | Binding | pKi 5.6 |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)MRP2 (Inhibitor)MRP3 (Inhibitor)MRP4 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (60)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Clinton | Tablet 30 mg | 10 tab pack varies | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 1.650 |
| Etoxib-120 | Tablet 120 mg | 7 tab | Noor Drug Store | 2.510 |
| Clinton | Tablet 60 mg | 10 tab pack varies | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 2.700 |
| Etoxa | Tablet 120 mg | 7 tab | Nabulsi Drug Store | 2.710 |
| STRYDE | Tablet 120 mg | 7 tab | Sukhtian Pharma Co. (SP) | 2.780 |
| Atoxia 60 mg F.C Tab | Film-Coated Tablet 60 mg | 10 tab pack varies | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 3.440 |
| STRYDE | Tablet 90 mg | 10 tab | Sukhtian Pharma Co. (SP) | 3.470 |
| Torix | Tablet Etoricoxib 60 mg | 14 tab pack varies | AL-TAQADDOM PHARMACEUTICAL INDUSTRIES/JORDAN | 3.480 |
| Clinton | Tablet 90 mg | 10 tab pack varies | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 3.750 |
| Etoria | Tablet 120 mg | 7 tab pack varies | Itqan Pharmaceutical Industries/Jordan | 3.770 |
| Orotix | Tablet 120 mg | 7 tab pack varies | Pharma International Company/ Jordan | 3.770 |
| Orotix | Tablet 60 mg | 14 tab pack varies | Pharma International Company/ Jordan | 3.890 |
| Savoxia | Tablet 120.0 mg | 7 tab | SAVVY PHARMA/JORDAN | 3.950 |
| Arcoxia Tab | Tablet 120 mg | 7 tab | Adatco Drug Store | 3.970 |
| Atoxia | Tablet 120 mg | 7 tab | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 3.970 |
| Clinton 120 mg F.C Tab | Film-Coated Tablet 120 mg | 7 tab pack varies | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 3.970 |
| Motacox 120mg Film-Coated Tablets | Film-Coated Tablet Etoricoxib 120 mg | 10 tab | Al-Motakadema Pharmaceutical LTD | 3.970 |
| Torix | Tablet 120 mg | 7 tab | Al-Taqqadom Pharmaceutical Industries | 3.970 |
| Etoria | Tablet 120 mg | 10 tab pack varies | Itqan Pharmaceutical Industries/Jordan | 4.000 |
| Etoria | Tablet 60.0 mg | 14 tab pack varies | Itqan Pharmaceutical Industries/Jordan | 4.390 |
| Coxit 120 mg F.C tab | Film-Coated Tablet 120 mg | 8 tab pack varies | Jordan Sweden Medical & Sterilization Co. | 4.540 |
| Arcoxia | Tablet 30 mg | 28 tab | Adatco Drug Store | 4.580 |
| Arcoxia Tab | Tablet 60 mg | 14 tab pack varies | Adatco Drug Store | 4.620 |
| coxit | Tablet 90 mg | 10 tab pack varies | Jordan Sweden Medical and Sterilization Co | 4.640 |
| Clinton | Tablet 30 mg | 30 tab pack varies | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 4.660 |
| Savoxia | Tablet 90.0 mg | 14 tab pack varies | SAVVY PHARMA/JORDAN | 4.810 |
| Savoxia | Tablet 60.0 mg | 14 tab pack varies | SAVVY PHARMA/JORDAN | 4.810 |
| Atoxia 90 mg F.C Tab | Film-Coated Tablet 90 mg | 10 tab pack varies | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 5.150 |
| Orotix | Tablet 120 mg | 10 tab pack varies | Pharma International Company/ Jordan | 5.390 |
| Clinton 120 mg F.C Tab | Film-Coated Tablet 120 mg | 10 tab pack varies | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 5.670 |
| Coxit 120 mg F.C tab | Film-Coated Tablet 120 mg | 10 tab pack varies | Jordan Sweden Medical & Sterilization Co. | 5.670 |
| Etoxib-60 | Tablet 60 mg | 28 tab | Noor Drug Store | 5.730 |
| Orotix | Tablet 90 mg | 14 tab pack varies | Pharma International Company/ Jordan | 6.250 |
| Etoria | Tablet 90.0 mg | 14 tab pack varies | Itqan Pharmaceutical Industries/Jordan | 6.490 |
| Etoxa | Tablet 60 mg | 30 tab | Nabulsi Drug Store | 6.610 |
| Torix | Tablet Etoricoxib 60 mg | 28 tab pack varies | AL-TAQADDOM PHARMACEUTICAL INDUSTRIES/JORDAN | 6.610 |
| Arcoxia Tab | Tablet 90 mg | 14 tab pack varies | Adatco Drug Store | 6.940 |
| Torix | Tablet 90 mg | 14 tab pack varies | Al-Taqqadom Pharmaceutical Industries | 7.210 |
| Clinton | Tablet 60 mg | 30 tab pack varies | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 7.640 |
| Orotix | Tablet 60 mg | 30 tab pack varies | Pharma International Company/ Jordan | 7.920 |
| Etoria | Tablet 60.0 mg | 28 tab pack varies | Itqan Pharmaceutical Industries/Jordan | 8.340 |
| Etoxib-90 | Tablet 90 mg | 28 tab | Noor Drug Store | 8.590 |
| Arcoxia Tab | Tablet 60 mg | 28 tab pack varies | Adatco Drug Store | 8.810 |
| Orotix | Tablet 90 mg | 20 tab pack varies | Pharma International Company/ Jordan | 8.930 |
| Etoria | Tablet 60.0 mg | 30 tab pack varies | Itqan Pharmaceutical Industries/Jordan | 8.940 |
| Savoxia | Tablet 90.0 mg | 28 tab pack varies | SAVVY PHARMA/JORDAN | 9.140 |
| Savoxia | Tablet 60.0 mg | 28 tab pack varies | SAVVY PHARMA/JORDAN | 9.140 |
| Etoxa | Tablet 90 mg | 30 tab | Nabulsi Drug Store | 9.210 |
| Etoria | Tablet 90.0 mg | 20 tab pack varies | Itqan Pharmaceutical Industries/Jordan | 9.270 |
| Atoxia 60 mg F.C Tab | Film-Coated Tablet 60 mg | 30 tab pack varies | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 9.810 |
| Motacox 90mg Film-Coated Tablets | Film-Coated Tablet 90 mg | 30 tab | Al-Motakadema Pharmaceutical LTD | 9.910 |
| Clinton | Tablet 90 mg | 30 tab pack varies | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 10.620 |
| Clinton 120 mg F.C Tab | Film-Coated Tablet 120 mg | 20 tab pack varies | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 10.770 |
| Etoria | Tablet 90.0 mg | 28 tab pack varies | Itqan Pharmaceutical Industries/Jordan | 12.330 |
| Orotix | Tablet 90 mg | 30 tab pack varies | Pharma International Company/ Jordan | 12.720 |
| coxit | Tablet 90 mg | 30 tab pack varies | Jordan Sweden Medical and Sterilization Co | 13.070 |
| Arcoxia Tab | Tablet 90 mg | 28 tab pack varies | Adatco Drug Store | 13.220 |
| Torix | Tablet 90 mg | 28 tab pack varies | Al-Taqqadom Pharmaceutical Industries | 13.740 |
| Atoxia 90 mg F.C Tab | Film-Coated Tablet 90 mg | 30 tab pack varies | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 14.720 |
| Clinton 120 mg F.C Tab | Film-Coated Tablet 120 mg | 1000 tab pack varies | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 482.070 |