Favipiravir
J05A - Direct acting antivirals
ATC J05AX27
Small molecule
approved 2014
Prodrug
Active form: Favipiravir-Rtp.
JFDA label: Sancovir 200 mg film coated tablet
Mechanism of Action
Inhibitor of RNA-directed RNA polymerase — RNA-directed RNA polymerase inhibitor
| Target | Action | Gene / class |
|---|---|---|
| RNA-directed RNA polymerase efficacy | INHIBITOR |
Indications
Off-label
- Hemorrhagic Fever, Ebola
- Influenza, Human
- Lassa Fever
- Severe Acute Respiratory Syndrome
- Virus Diseases
Pregnancy & Lactation
Lactation
Caution
Hale L3
Favipiravir has caused liver enzyme abnormalities, gastrointestinal symptoms, and serum uric acid elevations. If favipiravir is used in a nursing mother, these parameters should be monitored in the breastfed infant.
Chemistry & Properties
| Formula | C5H4FN3O2 |
|---|---|
| Molecular weight | 157.1 g/mol |
| IUPAC name | 5-fluoro-2-oxo-1H-pyrazine-3-carboxamide |
| CAS | 259793-96-9 |
| PubChem CID | 492405 |
| InChIKey | ZCGNOVWYSGBHAU-UHFFFAOYSA-N |
| logP | -0.58 (XLogP -0.6) |
| Polar surface area | 89.1 Ų |
| H-bond acceptors / donors | 4 / 2 |
| Drug-likeness (QED) | 0.57 |
| Lipinski violations | 0 |
SMILES
NC(=O)c1nc(F)cnc1OBiology & Pharmacokinetics
Pharmacokinetics predicted
| Bioavailability | 10.0% |
|---|---|
| Half-life | 1.961 h |
| Volume of distribution | 0.962 L/kg |
| Protein binding | 51.9% |
| BBB penetrant | No |
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP1A2 | Substrate | — |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MDR1 (Inhibitor)MRP1 (Inhibitor)OAT3 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (9)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Sancovir 200 mg film coated tablet | Film-Coated Tablet 200 mg | 40 tab pack varies | SANA PHARMACEUTICAL INDUSTRY/JORDAN | 13.360 |
| Sancovir 200 mg film coated tablet | Film-Coated Tablet 200 mg | 100 tab pack varies | SANA PHARMACEUTICAL INDUSTRY/JORDAN | 31.730 |
| Virix | Tablet 200 mg | 30 tab pack varies | SAVVY PHARMA/JORDAN | 48.000 |
| Avira tablet | Tablet 200 mg | 40 tab pack varies | JORDAN SWEDEN MEDICAL&STERILE.CO(JOSWE)/JORDAN | 54.270 |
| Virucid | Tablet 200 mg | 40 tab pack varies | Dar Al Dawa Development and Investment Co Ltd/Jordan | 54.270 |
| Avira tablet | Tablet 200 mg | 100 tab pack varies | JORDAN SWEDEN MEDICAL&STERILE.CO(JOSWE)/JORDAN | 129.210 |
| Virucid | Tablet 200 mg | 100 tab pack varies | Dar Al Dawa Development and Investment Co Ltd/Jordan | 129.210 |
| Virix | Tablet 200 mg | 100 tab pack varies | SAVVY PHARMA/JORDAN | 150.400 |
| Sancovir 200 mg film coated tablet | Film-Coated Tablet 200 mg | 1000 tab pack varies | SANA PHARMACEUTICAL INDUSTRY/JORDAN | 283.900 |