Flavonoid
C05C - Capillary stabilizing agents
ATC C05CA53
JFDA label: Daflon Tab
Dosing
Source: openFDA
Lidocaine HCl 4% Topical anesthetic
Warnings & Precautions
Source: openFDA
Warnings & Precautions
For external use only Flammable keep away from fire, sparks, and heated surfaces exposure to temperatures above 130°F may cause bursting store at room temperature in a dry place Do not use in large quantities, particularly over raw surfaces or blistered areas for more than one week without consulting a doctor if you have a hole in your ear drum or tubes in your ear
Chemistry & Properties
| Formula | C15H12O2 |
|---|---|
| Molecular weight | 224.25 g/mol |
| IUPAC name | 2-phenyl-2,3-dihydrochromen-4-one |
| CAS | 487-26-3 |
| PubChem CID | 10251 |
| InChIKey | ZONYXWQDUYMKFB-UHFFFAOYSA-N |
| logP | 3.2 (XLogP 3.2) |
| Polar surface area | 26.3 Ų |
| H-bond acceptors / donors | 2 / 0 |
SMILES
C1C(OC2=CC=CC=C2C1=O)C3=CC=CC=C3Biology & Pharmacokinetics
Pharmacokinetics predicted
| Bioavailability | 70.0% |
|---|---|
| Half-life | 1.843 h |
| Volume of distribution | 0.994 L/kg |
| Protein binding | 96.9% |
| BBB penetrant | Yes |
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP1A2 | Substrate | — |
| CYP2C19 | Inhibitor | — |
| CYP2C19 | Substrate | — |
| CYP2C8 | Inhibitor | — |
| CYP2C9 | Inhibitor | — |
| CYP3A4 | Inhibitor | — |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (1)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Daflon Tab | Tablet 500 mg | 30 tab | The Jordan Drugstore Co | 5.230 |