Fusidic Acid

JFDA label: Topidic Gel

Mechanism of Action

Inhibitor of Elongation factor G — Elongation factor G inhibitor

Target	Action	Gene / class
Elongation factor G efficacy	INHIBITOR	fusA · Unclassified protein

Indications

Approved

• Bacterial Infections — bacterial disease
• Eye Infections — eye infection

Off-label

• Carcinoma, Non-Small-Cell Lung
• Infections
• Keloid
• Skin Diseases

Antimicrobial Spectrum

Expected / intrinsic spectrum (EUCAST breakpoints & labels) — not local resistance. Source: EUCAST v16.

Bacteria

Organism	Activity	MIC
Staphylococcus spp.	Susceptible	1.0 mg/L

Pregnancy & Lactation

Chemistry & Properties

Formula	C31H48O6
Molecular weight	516.72 g/mol
IUPAC name	(2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid
CAS	6990-06-3
PubChem CID	3000226
InChIKey	IECPWNUMDGFDKC-MZJAQBGESA-N
logP	5.67 (XLogP 5.5)
Polar surface area	104.06 Ų
H-bond acceptors / donors	5 / 3
Drug-likeness (QED)	0.25
Lipinski violations	2

SMILES

CC(=O)O[C@H]1C[C@@]2(C)[C@@H](C[C@@H](O)[C@H]3[C@@]4(C)CC[C@@H](O)[C@@H](C)[C@@H]4CC[C@@]32C)/C1=C(\CCC=C(C)C)C(=O)O

Biology & Pharmacokinetics

Pharmacokinetics

BBB penetrant	No

Transporters

BCRP (Inhibitor)BCRP (Inhibitor)BSEP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)MRP2 (Inhibitor)MRP3 (Inhibitor)MRP4 (Inhibitor)OATP1B1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (30)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Fudion Cream	Cream 2 %	15 g tube	Noor Drug Store	1.470
Fusibact Cream	Cream 2 %	15 g tube	شركة مستودع ادوية الايمان	1.470
Zeta Cream	Cream 2 %	15gm	Sukhtian Group	1.470
Zydex Cream	Cream 2 %	15 g tube	Sukhtian Group	1.470
Dermofucin skin cream	Cream 2 %	15 g tube pack varies	Amman Pharmaceutical Indusries	1.680
Newsen Cream	Cream 2 %	15 g tube pack varies	Al-Gadeed Pharmaceutical Industries/JORDAN	1.800
Dermocid cream	Cream	15 gm	Dar Al Dawa Development and Investment Co Ltd/Jordan	2.000
Dermofucin Gel	Gel 2 %	15 g tube	Amman Pharmaceutical Indusries	2.000
Topidic Gel	Gel 2 %	15 g tube	Pharma International Company/ Jordan	2.000
Uciderm Cream	Cream 2 %	15 g tube	PHILADELPHIA PHAEMACEUTICALS.COMP/JORDAN	2.000
Uciderm Gel	Gel 2 %	15 g tube	PHILADELPHIA PHAEMACEUTICALS.COMP/JORDAN	2.000
Fusiderm Cream	Cream 2 %	15 g tube	Regional Drug Store	2.040
Fusiderm Ointment	Ointment 2 %	15 g tube	Regional Drug Store	2.040
Fusibact-B Cream	Cream 1.0 mg, 20 mg	15 g tube	شركة مستودع ادوية الايمان	2.080
FUCIDIN CREAM	Cream 2 %	15 g tube	Khoury Drug Store	2.100
Betafucin skin cream	Cream (Valerate)0.1 %, 2 %	15 g tube	Amman Pharmaceutical Indusries	2.300
Topizone Cream	Cream 0.1 %, 2 %	15 g tube	Pharma International Company/ Jordan	2.300
Ezaderm Cream	Cream 0.1 %, 2 %	15 gm	UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN	2.310
Newsen Cream	Cream 2 %	20 g tube pack varies	Al-Gadeed Pharmaceutical Industries/JORDAN	2.400
Uciderm B Cream	Cream 0.1 %, 2 %	15 g tube	PHILADELPHIA PHAEMACEUTICALS.COMP/JORDAN	2.580
Optifucin viscous eye drops	Ophthalmic Solution 1 %	5 g	Amman Pharmaceutical Indusries	2.690
Dermocid C	Cream 1 mg/1gm, 20 mg/1gm	15 gm	Dar Al Dawa Development and Investment Co Ltd/Jordan	2.710
Zydex-B Cream	Cream (as Valerate)0.1 %, 2 %	15 g tube	Sukhtian Group	2.710
Fucidin Gel	Gel 2 %	15 g tube	Arab Company for Medical & Agricultural Products	2.950
FUCICORT	Cream (as Valerate)1 mg/g, 20 mg/g	15 gm	Khoury Drug Store	2.970
Zydex-HC Cream	Cream 2 %, 1 %	15 g tube	Sukhtian Group	2.990
FUCITHALMIC VISCOUS	Cream 1 %	5 g tube	Arab Company for Medical & Agricultural Products	3.160
Dermofucin skin cream	Cream 2 %	30 g tube pack varies	Amman Pharmaceutical Indusries	3.190
Fucidin H Cream	Cream 20 mg/g, 10 mg/g	15 g tube	Khoury Drug Store	3.740
FUCIDIN SUSP.	Suspension 50 mg/ml	90 ml	Arab Company for Medical & Agricultural Products	12.020