Glucosamine

N - Nervous System ATC N/A Small molecule Natural product

JFDA label: Jamieson Glucosamine Chondroitin Complex Softgel Capsule

Mechanism of Action

— Supplement

Indications

Approved

Rheumatic Diseases — rheumatic disease

Off-label

Breast Neoplasms
Irritable Bowel Syndrome
Osteoarthritis
Osteoarthritis, Knee

Dosing

Source: openFDA

Direction Take one or two capsules daily with water, preferably with a meal, or as directed by your healthcare professional.

Warnings & Precautions

Source: openFDA

Warnings & Precautions

Other Ingredients Maize Starch, Microcrystalline Cellulose, Magnesium Stearate

Pregnancy & Lactation

Lactation

Caution Hale L3

Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or

Chemistry & Properties

Formula	C6H13NO5
Molecular weight	179.17 g/mol
IUPAC name	(3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
CAS	3416-24-8
PubChem CID	439213
InChIKey	`MSWZFWKMSRAUBD-IVMDWMLBSA-N`
logP	-3.25 (XLogP -2.8)
Polar surface area	116.17 Å²
H-bond acceptors / donors	6 / 5
Drug-likeness (QED)	0.29
Lipinski violations	0

SMILES

N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O

Biology & Pharmacokinetics

Pharmacokinetics predicted

Bioavailability	70.0%
Half-life	2.32 h
Volume of distribution	0.369 L/kg
Protein binding	22.3%
BBB penetrant	No

Enzyme interactions

Enzyme	Role	Detail
CYP2C19	Substrate	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)OATP1B3 (Inhibitor)OCT1 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Drug–drug interactions (2, DDInter)

Interacting drug	Severity	Management
Dicoumarol	moderate
Warfarin	moderate

Registered Products (1)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Jamieson Glucosamine Chondroitin Complex Softgel Capsule	Capsule 300 mg, 200 mg	10 cap	Al Farabe Drug Store	—