heparin, combinations
C05B - Antivaricose therapy
ATC C05BA53
JFDA label: Contractubex Gel
Chemistry & Properties
| Formula | C4H6N4O3 |
|---|---|
| Molecular weight | 158.12 g/mol |
| IUPAC name | (2,5-dioxoimidazolidin-4-yl)urea |
| CAS | 97-59-6 |
| PubChem CID | 204 |
| InChIKey | POJWUDADGALRAB-UHFFFAOYSA-N |
| logP | -2.2 (XLogP -2.2) |
| Polar surface area | 113.0 Ų |
| H-bond acceptors / donors | 3 / 4 |
SMILES
C1(C(=O)NC(=O)N1)NC(=O)NBiology & Pharmacokinetics
Pharmacokinetics predicted
| Bioavailability | 70.0% |
|---|---|
| Half-life | 2.294 h |
| Volume of distribution | 0.523 L/kg |
| Protein binding | 6.0% |
| BBB penetrant | No |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (2)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Contractubex Gel | Gel 1 g/100 g, 10 g/100 g, 5000 IU/100 g | 20 g tube pack varies | Jarash Drug Store | 4.710 |
| Contractubex Gel | Gel 1 g/100 g, 10 g/100 g, 5000 IU/100 g | 50 g tube pack varies | Jarash Drug Store | 7.790 |