Isoconazole

JFDA label: TRAVOCORT CREAM

Pregnancy & Lactation

Chemistry & Properties

Formula	C18H14Cl4N2O
Molecular weight	416.13 g/mol
IUPAC name	1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]imidazole
CAS	27523-40-6
PubChem CID	3760
InChIKey	MPIPASJGOJYODL-UHFFFAOYSA-N
logP	6.45 (XLogP 5.3)
Polar surface area	27.05 Ų
H-bond acceptors / donors	3 / 0
Drug-likeness (QED)	0.46
Lipinski violations	1

SMILES

Clc1ccc(C(Cn2ccnc2)OCc2c(Cl)cccc2Cl)c(Cl)c1

Biology & Pharmacokinetics

Pharmacokinetics predicted

Bioavailability	35.0%
Half-life	1.523 h
Volume of distribution	3.244 L/kg
Protein binding	94.1%
BBB penetrant	No

Enzyme interactions

Enzyme	Role	Detail
CYP1A2	Inhibitor	—
CYP1A2	Substrate	—
CYP2B6	Inhibitor	—
CYP2C19	Inhibitor	—
CYP2C8	Inhibitor	—
CYP2C9	Inhibitor	—
CYP2D6	Inhibitor	—
CYP3A4	Inhibitor	—
CYP3A4	Substrate	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (10)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Vocozole Cream	Cream 1 %	15 g tube pack varies	PHILADELPHIA PHAEMACEUTICALS.COMP/JORDAN	1.400
Azonit cream	Cream 1 %	20 gm pack varies	Pharma International Company/ Jordan	1.800
Vocort Cream	Cream 1 %, 0.1 %	15 g tube pack varies	PHILADELPHIA PHAEMACEUTICALS.COMP/JORDAN	2.150
TRAVOGEN CREAM	Cream 10 mg/g	20 g tube	Khoury Drug Store	2.200
Isocort skin Cream	Cream 1 %, 0.1 %	15 gm	Amman Pharmaceutical Indusries	2.250
Vocozole Cream	Cream 1 %	30 g tube pack varies	PHILADELPHIA PHAEMACEUTICALS.COMP/JORDAN	2.660
Azonit-D cream	Cream 1 %, 0.1 %	20 g tube	Pharma International Company/ Jordan	2.700
Vocort Cream	Cream 1 %, 0.1 %	30 g tube pack varies	PHILADELPHIA PHAEMACEUTICALS.COMP/JORDAN	3.000
Azonit Vaginal cream	Cream 1 %	40 g tube pack varies	Pharma International Company/ Jordan	3.200
TRAVOCORT CREAM	Cream 10 mg/g, 1 mg/g	20 g tube	Khoury Drug Store	3.520