Ivy
R05C - Expectorants, excl. combinations with cough suppressants
ATC VI
JFDA label: Prospan Cough supp
Dosing
Source: openFDA
Place drops under tongue 30 minutes before/after meals. Adults and children 12 years and over: Take 10 to 15 drops up to 3 times per day. For desensitization, begin with 1 to 5 drops daily, increasing to the standard dose gradually to avoid symptom expression; after 1 to 3 months at the standard dose, decrease gradually to a maintenance dose of 10 to 15 drops weekly. Consult a physician for use in children under 12 years of age.
Warnings & Precautions
Source: openFDA
Warnings & Precautions
Severe symptoms such as difficulty breathing, facial swelling, dizziness, confusion, and hives may be life-threatening and require immediate emergency care. Keep out of the reach of children. In case of overdose, get medical help or contact a poison control center right away. If pregnant or breastfeeding, ask a healthcare professional before use. Keep out of the reach of children. If pregnant or breastfeeding, ask a healthcare professional before use.
Chemistry & Properties
| Formula | C20H12F4N4O |
|---|---|
| Molecular weight | 400.3 g/mol |
| IUPAC name | 3-[2-(2-fluorophenyl)pyrazol-3-yl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4-one |
| PubChem CID | 46219816 |
| InChIKey | SABOFQQPIQQDHH-UHFFFAOYSA-N |
| logP | 4.5 (XLogP 4.5) |
| Polar surface area | 50.5 Ų |
| H-bond acceptors / donors | 8 / 0 |
SMILES
C1=CC=C(C(=C1)N2C(=CC=N2)C3=NN(C=CC3=O)C4=CC=CC(=C4)C(F)(F)F)FBiology & Pharmacokinetics
Pharmacokinetics predicted
| Bioavailability | 10.0% |
|---|---|
| Half-life | 0.855 h |
| Volume of distribution | 2.266 L/kg |
| Protein binding | 97.9% |
| BBB penetrant | Yes |
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP1A2 | Inhibitor | — |
| CYP1A2 | Substrate | — |
| CYP2C19 | Inhibitor | — |
| CYP2C8 | Inhibitor | — |
| CYP2C9 | Inhibitor | — |
| CYP3A4 | Inhibitor | — |
| CYP3A4 | Substrate | — |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (3)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Prospan Cough supp | Suppository 80 mg | 10 supp | Pharma Care Drug Store | 2.480 |
| Dilamuc | Solution 0.17 g/100 ml, 0.76 g/100 ml, 0.164 g/100 ml | 100 ml pack varies | JERASH PHARMACEUTICALS LTD.CO/JORDAN | 2.850 |
| Dilamuc | Solution 0.17 g/100 ml, 0.76 g/100 ml, 0.164 g/100 ml | 120 ml pack varies | JERASH PHARMACEUTICALS LTD.CO/JORDAN | 3.410 |