L-Leucine
J01 - Antibacterials for systemic use
Small molecule
Natural product
JFDA label: IRIDIUM A Gel Monodose (ophthalmic gel)
Indications
Off-label
- Anemia, Diamond-Blackfan
- Depressive Disorder, Major
- Diabetes Mellitus, Type 2
Dosing
Source: openFDA
Adults and children take four droppers full twice a day for stamina building and muscle recovery; best if taken 1/2 hour prior to workout. For more strenuous workouts, dosage may be increased to eight droppers full. Consult a physician for use in children under 12 years of age.
Warnings & Precautions
Source: openFDA
Warnings & Precautions
If pregnant or breastfeeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. Do not use if tamper evident seal is broken or missing. Store in a cool, dry place.
Chemistry & Properties
| Formula | C6H13NO2 |
|---|---|
| Molecular weight | 131.17 g/mol |
| IUPAC name | (2S)-2-amino-4-methylpentanoic acid |
| CAS | 61-90-5 |
| PubChem CID | 6106 |
| InChIKey | ROHFNLRQFUQHCH-YFKPBYRVSA-N |
| logP | 0.44 (XLogP -1.5) |
| Polar surface area | 63.32 Ų |
| H-bond acceptors / donors | 2 / 2 |
| Drug-likeness (QED) | 0.58 |
| Lipinski violations | 0 |
SMILES
CC(C)C[C@H](N)C(=O)OBiology & Pharmacokinetics
Pharmacokinetics predicted
| Bioavailability | 10.0% |
|---|---|
| Half-life | 0.865 h |
| Volume of distribution | 0.758 L/kg |
| Protein binding | 24.0% |
| BBB penetrant | No |
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP2C8 | Inhibitor | — |
| CYP2D6 | Substrate | — |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (4)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| IRIDIUM A Gel Monodose (ophthalmic gel) | Ophthalmic Solution 0.0108 %w/w, 0.0140 %w/w, 0.0752 %w/w, 0.2000 %w/w, 0.1000 %w/w, 0.2000 %w/w, 0.2000 %w/w | 0.5 ml | مستودع أدوية المتنبي | — |
| Olimel N12E | Solution Alanine 10.99 g/1000 ml, Arginine 7.44 g/1000 ml, L-Aspartic acid 2.20 g/1000 ml, Glutamic acid 3.79 g/1000 ml, Glycine 5.26 g/1000 ml, HISTIDINE 4.53 g/1000 ml, isoleucine 3.79 g/1000 ml, Leucine 5.26 g/1000 ml, Lysine acetate 8.43 g/1000 ml, methionine 3.79 g/1000 ml, phenylalanine 5.26 g/1000 ml, proline 4.53 g/1000 ml, Serine 3 g/1000 ml, threonine 3.79 g/1000 ml, Tryptophan 1.26 g/1000 ml, Tyrosine 0.2 g/1000 ml, valine 4.86 g/1000 ml, Sodium Acetate Trihydrate 1.5 g/1000 ml, Sodium Glycerophosphate (Liq 50 %) 3.67 g/1000 ml, Potassium Chloride 2.24 g/1000 ml, Magnesium Chloride Hexahydrate 0.81 g/1000 ml, Calcium Chloride Dihydrated 0.52 g/1000 ml, Glucose Monohydrate 80.67 g/1000 ml, Olive Oil 28 g/1000 ml, Soyabean Oil 7 g/1000 ml | 1000 ml | Khoury Drug Store | — |
| Olimel N12E | Solution Alanine 7.14 g/650 ml, Arginine 4.84 g/650 ml, L-Aspartic acid 1.43 g/650 ml, Glutamic acid 2.46 g/650 ml, Glycine 3.42 g/650 ml, HISTIDINE 2.94 g/650 ml, isoleucine 2.46 g/650 ml, Leucine 3.42 g/650 ml, Lysine acetate 5.48 g/650 ml, methionine 2.46 g/650 ml, phenylalanine 3.42 g/650 ml, proline 2.94 g/650 ml, Serine 1.95 g/650 ml, threonine 2.46 g/650 ml, Tryptophan 0.82 g/650 ml, Tyrosine 0.13 g/650 ml, valine 3.16 g/650 ml, Sodium Acetate Trihydrate 0.97 g/650 ml, Sodium Glycerophosphate (Liq 50 %) 2.39 g/650 ml, Potassium Chloride 1.45 g/650 ml, Magnesium Chloride Hexahydrate 0.53 g/650 ml, Calcium Chloride Dihydrated 0.34 g/650 ml, Glucose Monohydrate 52.43 g/650 ml, Olive Oil 18.2 g/650 ml, Soyabean Oil 4.55 g/650 ml | 650 ml | Khoury Drug Store | — |
| PeriOlimel N4E | Solution Arginine 3.72 g/1500 ml, L-Aspartic acid 1.1 g/1500 ml, Glutamic acid 1.90 g/1500 ml, Glycine 2.63 g/1500 ml, HISTIDINE 2.26 g/1500 ml, isoleucine 1.90 g/1500 ml, Leucine 2.63 g/1500 ml, Lysine acetate 4.21 g/1500 ml, methionine 1.90 g/1500 ml, phenylalanine 2.63 g/1500 ml, proline 2.26 g/1500 ml, Serine 1.5 g/1500 ml, threonine 1.9 g/1500 ml, Tryptophan 0.64 g/1500 ml, Tyrosine 0.1 g/1500 ml, valine 2.43 g/1500 ml, Sodium Acetate Trihydrate 1.73 g/1500 ml, Sodium Glycerophosphate (Liq 50 %) 2.87 g/1500 ml, Potassium Chloride 1.79 g/1500 ml, Magnesium Chloride Hexahydrate 0.67 g/1500 ml, Calcium Chloride Dihydrated 0.440 g/1500 ml, Glucose Monohydrate 123.75 g/1500 ml, Olive Oil 45 g/1500 ml, Soyabean Oil 45 g/1500 ml, Alanine 5.5 g/1500 ml | 1500 ml | Khoury Drug Store | — |