Lornoxicam

M01A - NSAIDs and antirheumatic products, non-steroids ATC M01AC05 Small molecule Natural product

JFDA label: Xefo 8mg Tablets

Mechanism of Action

Inhibitor of Cyclooxygenase — Cyclooxygenase inhibitor

Target	Action	Gene / class
Cyclooxygenase efficacy	INHIBITOR

Indications

Approved

Rheumatic Diseases — rheumatic disease

Off-label

Alzheimer Disease
Migraine Disorders
Pain

Class profile

cox1_IC50_uM	1.7
cox2_IC50_uM	3.3
cox2_selectivity	0.5151515151515151
inhibitionType	reversible
preferentialCOX2	0
selectiveCOX2	0
plateletEffect	1
source	Warner1999/Vane1996/ChEMBL

Pregnancy & Lactation

Pregnancy

Lactation

Caution Hale L3

An alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Monitoring

Efficacy	Pain and inflammation control (VAS/NRS scores, joint mobility, functional status); minimum effective dose
Toxicity	Blood pressure (raises BP, antagonises antihypertensives); renal function (SCr, eGFR — especially in elderly, heart failure, CKD, dehydrated); Hb/faecal occult blood (GI bleeding); LFTs; oedema
Clinical pearl	Use the lowest effective dose for the shortest duration. Consider co-prescribing a proton pump inhibitor if GI risk factors present. COX-2 selective agents reduce GI but not CV risk.
Counseling	Take with food or milk to reduce GI upset. Report black stools, blood in urine, or significant ankle swelling. Monitor blood pressure regularly if hypertensive.

Chemistry & Properties

Formula	C13H10ClN3O4S2
Molecular weight	371.83 g/mol
IUPAC name	6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide
CAS	70374-39-9
PubChem CID	54690031
InChIKey	`WLHQHAUOOXYABV-UHFFFAOYSA-N`
logP	2.3 (XLogP 2.1)
Polar surface area	99.6 Å²
H-bond acceptors / donors	6 / 2
Drug-likeness (QED)	0.84
Lipinski violations	0

SMILES

CN1C(C(=O)Nc2ccccn2)=C(O)c2sc(Cl)cc2S1(=O)=O

Biology & Pharmacokinetics

Pharmacokinetics

BBB penetrant	Yes

Enzyme interactions

Enzyme	Role	Detail
CYP2C19	Inhibitor	—
CYP2C9	Inhibitor	—
CYP2C9	Substrate	—
CYP3A4	Substrate	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)MRP2 (Inhibitor)MRP4 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)OATP2B1 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (17)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Xefo Rapid	Film-Coated Tablet 8 mg	10 F.C Tab	The Arab Pharmaceutical Manufacturing PSC/Salt	2.430
Veloce	Tablet 8 mg	10 tab pack varies	UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN	2.560
Xenodol 8mg F.C Tab	Film-Coated Tablet 8 mg	10 tab pack varies	Hayat Pharmaceutical Industries CO.PLC/JORDAN	2.560
Loral	Tablet 8 mg	10 tab pack varies	Al-Taqqadom Pharmaceutical Industries	2.570
Opal F.C Tab	Film-Coated Tablet 8 mg	10 tab pack varies	Dar Al Dawa Development and Investment Co Ltd/Jordan	2.680
Veloce	Vial 8 mg	1 vial pack varies	MS PHARMA/JORDAN	2.800
Xefo	Tablet 8 mg	10 tab pack varies	Hikma Pharmaceuticals Co.Ltd/Jordan	3.200
Xefo 8 Powder for Injection	Powder for Injection 8 mg	1 vial pack varies	Hikma Pharmaceuticals Co.Ltd/Jordan	3.500
Xenodol 8mg F.C Tab	Film-Coated Tablet 8 mg	14 tab pack varies	Hayat Pharmaceutical Industries CO.PLC/JORDAN	3.580
Loral	Tablet 8 mg	20 tab pack varies	Al-Taqqadom Pharmaceutical Industries	4.880
Opal F.C Tab	Film-Coated Tablet 8 mg	20 tab pack varies	Dar Al Dawa Development and Investment Co Ltd/Jordan	5.110
Veloce	Tablet 8 mg	20 tab pack varies	UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN	5.110
Xenodol 8mg F.C Tab	Film-Coated Tablet 8 mg	20 tab pack varies	Hayat Pharmaceutical Industries CO.PLC/JORDAN	5.110
roxi	Tablet 8 mg	20 tab	AL-RAM PHARMA.INDUS.CO.LTD/JORDAN	5.110
Xefo	Tablet 8 mg	20 tab pack varies	Hikma Pharmaceuticals Co.Ltd/Jordan	6.390
Xenodol 8mg F.C Tab	Film-Coated Tablet 8 mg	28 tab pack varies	Hayat Pharmaceutical Industries CO.PLC/JORDAN	7.160
Loral	Tablet 8 mg	30 tab pack varies	Al-Taqqadom Pharmaceutical Industries	7.250