Mebeverine
A03A - Drugs for functional bowel disorders
ATC A03AA04
Small molecule
Natural product
JFDA label: Mebetalin 135 mg tablets
Indications
Approved
- Digestive System Diseases — gastrointestinal disease
Off-label
- Irritable Bowel Syndrome
Adverse Reactions
Very Common >10%Common 1–10%Uncommon 0.1–1%
Rare 0.01–0.1%Very Rare <0.01%Not Known
Nervous system disorders (2)
Not Known Dizziness · Headache
Immune system disorders (3)
Not Known Anaphylactic shock · Hypersensitivity · Immune system disorder
Gastrointestinal disorders (2)
Not Known Decreased appetite · Dyspepsia
Skin and subcutaneous tissue disorders (4)
Not Known Angioedema · Dermatitis · Rash · Urticaria
Psychiatric disorders (1)
Not Known Insomnia
Investigations (1)
Not Known Feeling abnormal
General disorders and administration site conditions (4)
Not Known Discomfort · Face oedema · Ill-defined disorder · Malaise
Pregnancy & Lactation
Pregnancy
Chemistry & Properties
| Formula | C25H35NO5 |
|---|---|
| Molecular weight | 429.56 g/mol |
| IUPAC name | 4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl 3,4-dimethoxybenzoate |
| CAS | 3625-06-7 |
| PubChem CID | 4031 |
| InChIKey | VYVKHNNGDFVQGA-UHFFFAOYSA-N |
| logP | 4.6 (XLogP 5.2) |
| Polar surface area | 57.23 Ų |
| H-bond acceptors / donors | 6 / 0 |
| Drug-likeness (QED) | 0.34 |
| Lipinski violations | 0 |
SMILES
CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1Biology & Pharmacokinetics
Pharmacokinetics
| BBB penetrant | No |
|---|
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP1A2 | Substrate | — |
| CYP2B6 | Inhibitor | — |
| CYP2C19 | Substrate | — |
| CYP2D6 | Inhibitor | — |
| CYP2D6 | Substrate | — |
| CYP3A4 | Inhibitor | — |
| CYP3A4 | Substrate | — |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (9)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Mebetalin | Tablet 135 mg | 30 tab pack varies | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 2.200 |
| Bevacol F.C tablet | Film-Coated Tablet 135 mg | 32 tab pack varies | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 2.350 |
| Bevacol F.C tablet | Film-Coated Tablet 135 mg | 48 tab pack varies | THE JORDANIAN PHARMACEUTICAL MANUFACTURING COMPANY/JORDAN | 3.520 |
| Mebetalin | Tablet 135 mg | 50 tab pack varies | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 3.670 |
| Bevetalin Tablets | Tablet 135 mg | 50 tab pack varies | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 3.800 |
| Duspatalin Tab | Tablet 135 mg | 50 tab | Abu Sheikha Drug Store | 5.190 |
| Duspatalin Ret | Tablet 200 mg | 30 tab | Abu Sheikha Drug Store | 6.380 |
| Mebetalin | Tablet 135 mg | 1000 tab pack varies | AL-RAM PHARMA.INDUS.CO.LTD/JORDAN | 58.760 |
| Bevetalin Tablets | Tablet 135 mg | 1000 tab pack varies | UNITED PHARM.MFG.CO.LTD(UPM)/JORDAN | 64.600 |