Menthol

R06A - Antihistamines for systemic use ATC R06AA02 Small molecule approved 2008 Topical Natural product

JFDA label: PECTOLYN DECONGESTANT

Mechanism of Action

Opener of Transient receptor potential cation channel subfamily M member 8 — Transient receptor potential cation channel subfamily M member 8 opener; Opener of Transient receptor potential cation channel subfamily A member 1 — Transient receptor potential cation channel subfamily A member 1 opener

Target	Action	Gene / class
Transient receptor potential cation channel subfamily A member 1 efficacy	OPENER	TRPA1
Transient receptor potential cation channel subfamily M member 8 efficacy	OPENER	TRPM8

Indications

Approved

Protective barrier

Contraindications

Source: Lexicomp

OTC labeling: When used for self-medication, do not use in the eyes, on deep or puncture wounds, on animal bites, or on serious burns Absolute

Adverse Reactions

Very Common >10%Common 1–10%Uncommon 0.1–1% Rare 0.01–0.1%Very Rare <0.01%Not Known

Immune system disorders (1)

Not Known Hypersensitivity reaction

Skin and subcutaneous tissue disorders (3)

Not Known Pruritus · skin rash · stinging of the skin (temporarily on application)

Dosing

Source: Lexicomp

Protective barrier: Topical: Ointment (excluding Lantiseptic): Apply thin layer to affected area 2 to 4 times daily or after each incontinent episode/diaper change Ointment (Lantiseptic only), Paste: Apply to affected area up to 6 times daily or after each incontinent episode/diaper change Powder: Children ≥2 years, Adolescents, and Adults: Apply to affected area up to 4 times daily.

Protective barrier: Topical: Ointment (excluding Lantiseptic): Children and Adolescents: Refer to adult dosing. Ointment (Lantiseptic only), Paste: Children ≥12 years and Adolescents: Refer to adult dosing. Powder: Children ≥2 years and Adolescents: Refer to adult dosing.

There are no dosage adjustments provided in the manufacturer’s labeling.

There are no dosage adjustments provided in the manufacturer’s labeling

Warnings & Precautions

Source: Lexicomp

Allergic reactions

May occur; discontinue use if redness, irritation, swelling, pain, or other symptoms develop. Disease-related concerns:

Radiation therapy

Zinc oxide cannot be used during radiation therapy. Other warnings/precautions:

Self-medication (OTC use)

Do not exceed the recommended dose unless directed by a health care provider; do not put medication into rectum using fingers or any mechanical device/applicator. If the symptom being treated does not subside, worsens, does not improve within 7 days or if redness, irritation, swelling, pain, bleeding, or other symptoms develop or increase, discontinue use and consult a health care provider.

Pregnancy & Lactation

Pregnancy

Chemistry & Properties

Formula	C10H20O
Molecular weight	156.27 g/mol
IUPAC name	5-methyl-2-propan-2-ylcyclohexan-1-ol
CAS	1490-04-6
PubChem CID	1254
InChIKey	`NOOLISFMXDJSKH-UHFFFAOYSA-N`
logP	2.44 (XLogP 3.0)
Polar surface area	20.23 Å²
H-bond acceptors / donors	1 / 1
Drug-likeness (QED)	0.62
Lipinski violations	0

SMILES

CC1CCC(C(C)C)C(O)C1

Biology & Pharmacokinetics

Pharmacokinetics

BBB penetrant	No

Enzyme interactions

Enzyme	Role	Detail
CYP2B6	Inhibitor	—
CYP2C19	Substrate	—
CYP2C8	Inhibitor	—
CYP2C9	Substrate	—
CYP3A4	Substrate	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (10)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
PECTOLYN PEDIATRIC	Suspension 125 mg/5 ml, 0.55 mg/5 ml, 7 mg/5 ml, 28.5 mg/ml	150 ml	Dar Al Dawa Development and Investment Co Ltd/Jordan	0.790
PECTOLYN DECONGESTANT	Suspension 1.1 mg/5 ml, 57 mg/5 ml, 22.5 mg/5 ml, 14 mg/5 ml	150 ml	Dar Al Dawa Development and Investment Co Ltd/Jordan	0.850
diclosal Emulgel	Gel 1.4 %, 2.5 %, 1 %	25 g tube pack varies	MIDDLE EAST PHARMA&CHEMICAL IND/JORDAN	1.060
proctolain oint.	Ointment 20 mg, 2.5 mg, 50 mg	30 g tube	MIDDLE EAST PHARMA&CHEMICAL IND/JORDAN	1.150
proctolain supp.	Suppository 40 mg, 5 mg, 100 mg	10 pack varies	MIDDLE EAST PHARMA&CHEMICAL IND/JORDAN	1.150
proctolar center oint.	Ointment 2 %, 0.01 %, 0.25 %, 5 %	15 g tube pack varies	Arab Center for Pharmaceuticals & Chemicals	1.350
diclosal Emulgel	Gel 1.4 %, 2.5 %, 1 %	50 g tube pack varies	MIDDLE EAST PHARMA&CHEMICAL IND/JORDAN	2.010
proctolar center supp	Suppository 0.1 mg, 5 mg, 100 mg, 40 mg	10	MIDDLE EAST PHARMA&CHEMICAL IND/JORDAN	2.030
proctolar center oint.	Ointment 2 %, 0.01 %, 0.25 %, 5 %	30 g tube pack varies	Arab Center for Pharmaceuticals & Chemicals	2.470
proctolain supp.	Suppository 40 mg, 5 mg, 100 mg	100 pack varies	MIDDLE EAST PHARMA&CHEMICAL IND/JORDAN	10.350