Metixene
N04A - Anticholinergic agents
ATC N04AA03
Small molecule
approved 1982
Oral
Natural product
JFDA label: SPASMO-CANULASE Tab
Indications
Approved
- Parkinson Disease — Parkinson disease
Chemistry & Properties
| Formula | C20H23NS |
|---|
| Molecular weight | 309.48 g/mol |
|---|
| IUPAC name | 1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine |
|---|
| CAS | 4969-02-2 |
|---|
| PubChem CID | 4167 |
|---|
| InChIKey | MJFJKKXQDNNUJF-UHFFFAOYSA-N |
|---|
| logP | 5.02 (XLogP 4.9) |
|---|
| Polar surface area | 3.24 Ų |
|---|
| H-bond acceptors / donors | 2 / 0 |
|---|
| Drug-likeness (QED) | 0.77 |
|---|
| Lipinski violations | 1 |
|---|
SMILES
CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1Biology & Pharmacokinetics
Pharmacokinetics
Enzyme interactions
| Enzyme | Role | Detail |
|---|
| CYP1A2 | Substrate |
— |
| CYP2B6 | Substrate |
— |
| CYP2C19 | Substrate |
— |
| CYP2C9 | Substrate |
— |
| CYP2D6 | Inhibitor |
— |
| CYP2D6 | Substrate |
— |
| CYP3A4 | Substrate |
— |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (1)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|
| SPASMO-CANULASE Tab
combo
|
Tablet 1+40+100 mg |
20 tab |
Nabulsi Drug Store |
5.560 |