Nadifloxacin
D10A - Anti-acne preparations for topical use
ATC D06AX
Small molecule
JFDA label: Nadixa
Mechanism of Action
Inhibitor of Bacterial DNA gyrase — Bacterial DNA gyrase inhibitor; Inhibitor of Topoisomerase IV — Topoisomerase IV inhibitor
| Target | Action | Gene / class |
|---|---|---|
| Bacterial DNA gyrase efficacy | INHIBITOR | |
| Topoisomerase IV efficacy | INHIBITOR |
Indications
Off-label
- Acne Vulgaris
Pregnancy & Lactation
Pregnancy
Chemistry & Properties
| Formula | C19H21FN2O4 |
|---|---|
| Molecular weight | 360.38 g/mol |
| IUPAC name | 7-fluoro-8-(4-hydroxypiperidin-1-yl)-12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene-3-carboxylic acid |
| CAS | 124858-35-1 |
| PubChem CID | 4410 |
| InChIKey | JYJTVFIEFKZWCJ-UHFFFAOYSA-N |
| logP | 2.31 (XLogP 2.9) |
| Polar surface area | 82.77 Ų |
| H-bond acceptors / donors | 5 / 2 |
| Drug-likeness (QED) | 0.86 |
| Lipinski violations | 0 |
SMILES
CC1CCc2c(N3CCC(O)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23Biology & Pharmacokinetics
Pharmacokinetics
| BBB penetrant | No |
|---|
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (2)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Sanadix | Cream 1GM/100 g | (25 GM) / TUB | Sana Pharmaceutical Industry Company | 4.940 |
| Nadixa | Cream 1 % | 25 gm | Ibn Rushd Drug Store | 6.170 |