Nandrolone
A14A - Anabolic steroids
ATC A14AB01
Small molecule
Natural product
JFDA label: DECA DURABOLIN INJ
Indications
Off-label
- Anemia, Aplastic
Adverse Reactions
Very Common >10%Common 1–10%Uncommon 0.1–1%
Rare 0.01–0.1%Very Rare <0.01%Not Known
Vascular disorders (1)
Not Known Haemorrhage
Nervous system disorders (1)
Not Known Gynaecomastia
Hepatobiliary disorders (1)
Not Known Peliosis hepatis
Blood and lymphatic system disorders (1)
Not Known Haemoglobin
Gastrointestinal disorders (3)
Not Known Diarrhoea · Nausea · Vomiting
Skin and subcutaneous tissue disorders (2)
Not Known Acne · Alopecia
Psychiatric disorders (3)
Not Known Insomnia · Irritability · Libido decreased
Reproductive system and breast disorders (3)
Not Known Erectile dysfunction · Priapism · Testicular atrophy
Investigations (1)
Not Known Glucose tolerance decreased
General disorders and administration site conditions (8)
Not Known Azoospermia · Disturbance in sexual arousal · Drug interaction · Enlarged clitoris · Epididymitis · Hirsutism · Menstruation irregular · Oedema
Neoplasms benign, malignant and unspecified (incl cysts and polyps) (1)
Not Known Neoplasm
Chemistry & Properties
| Formula | C18H26O2 |
|---|---|
| Molecular weight | 274.4 g/mol |
| IUPAC name | (8R,9S,10R,13S,14S,17S)-17-hydroxy-13-methyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one |
| CAS | 434-22-0 |
| PubChem CID | 9904 |
| InChIKey | NPAGDVCDWIYMMC-IZPLOLCNSA-N |
| logP | 3.49 (XLogP 2.6) |
| Polar surface area | 37.3 Ų |
| H-bond acceptors / donors | 2 / 1 |
| Drug-likeness (QED) | 0.73 |
| Lipinski violations | 0 |
SMILES
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@H]43)[C@@H]1CC[C@@H]2OBiology & Pharmacokinetics
Pharmacokinetics
| BBB penetrant | No |
|---|
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP1A2 | Substrate | — |
| CYP2C19 | Substrate | — |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)OCT1 (Inhibitor)P-gp (Inhibitor)MRP2 (Substrate)P-gp (Substrate)
Registered Products (1)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| DECA DURABOLIN INJ | Injection 50 mg/ml | 1 Glass Ampoule | Sabbagh Drug Store | 3.720 |