Nicergoline

C04A - Peripheral vasodilators ATC C04AE02 Small molecule Natural product

JFDA label: SERMION Tab

Indications

Approved

Cardiovascular Diseases — cardiovascular disease

Off-label

Anxiety
Deglutition Disorders
Dementia
Depressive Disorder
Schizophrenia

Chemistry & Properties

Formula	C24H26BrN3O3
Molecular weight	484.39 g/mol
IUPAC name	[(6aR,9R,10aS)-10a-methoxy-4,7-dimethyl-6a,8,9,10-tetrahydro-6H-indolo[4,3-fg]quinolin-9-yl]methyl 5-bromopyridine-3-carboxylate
CAS	27848-84-6
PubChem CID	34040
InChIKey	`YSEXMKHXIOCEJA-FVFQAYNVSA-N`
logP	3.91 (XLogP 3.2)
Polar surface area	56.59 Å²
H-bond acceptors / donors	6 / 0
Drug-likeness (QED)	0.53
Lipinski violations	0

SMILES

CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13

Biology & Pharmacokinetics

Pharmacokinetics

BBB penetrant	Yes

Enzyme interactions

Enzyme	Role	Detail
CYP1A2	Inhibitor	—
CYP1A2	Substrate	—
CYP2B6	Inhibitor	—
CYP2C19	Inhibitor	—
CYP2C8	Inhibitor	—
CYP2D6	Inhibitor	—
CYP2D6	Substrate	—
CYP3A4	Inhibitor	—
CYP3A4	Substrate	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (1)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
SERMION Tab	Tablet 5 mg	30 tab	Khoury Drug Store	2.300