Otilonium
A03A - Drugs for functional bowel disorders
ATC A03AB06
Small molecule
Natural product
JFDA label: Spasmomen
Chemistry & Properties
| Formula | C29H43N2O4+ |
|---|
| Molecular weight | 483.67 g/mol |
|---|
| IUPAC name | diethyl-methyl-[2-[4-[(2-octoxybenzoyl)amino]benzoyl]oxyethyl]azanium |
|---|
| CAS | 105360-89-2 |
|---|
| PubChem CID | 72093 |
|---|
| InChIKey | NQHNLNLJPDMBFN-UHFFFAOYSA-O |
|---|
| logP | 6.32 (XLogP 6.8) |
|---|
| Polar surface area | 64.63 Ų |
|---|
| H-bond acceptors / donors | 4 / 1 |
|---|
| Drug-likeness (QED) | 0.17 |
|---|
| Lipinski violations | 1 |
|---|
SMILES
CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1Biology & Pharmacokinetics
Pharmacokinetics
Enzyme interactions
| Enzyme | Role | Detail |
|---|
| CYP2B6 | Inhibitor |
— |
| CYP2D6 | Inhibitor |
— |
| CYP2D6 | Substrate |
— |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (3)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|
| Spanol
|
Tablet 40 mg |
30 tab |
شركة مستودع ادوية جرينلاند |
2.560 |
| Ibronal
|
Tablet 40 mg |
30 tab |
SAVVY PHARMA/JORDAN |
3.000 |
| Spasmomen
|
Tablet 40 mg |
30 tab |
ORIENT DRUG STORE CO |
3.610 |