Piperonyl Butoxide
JFDA label: Licesol
Mechanism of Action
Inhibitor of Cytochrome P450 — Cytochrome P450 inhibitor
| Target | Action | Gene / class |
|---|---|---|
| Cytochrome P450 efficacy | INHIBITOR |
Dosing
Source: openFDA
Warnings & Precautions
Source: openFDA
Warnings & Precautions
Warnings For external use only Do not use near eyes inside nose, mouth, or vagina on lice in eyebrows or eyelashes. See a doctor if lice are present in these areas. Ask a doctor before use if you are allergic to ragweed. May cause breathing difficulty or an asthmatic attack. When using this product keep eyes tightly closed and protect eyes with a washcloth or towel if product gets into eyes, flush with water right away scalp itching or redness may occur Stop use and ask a doctor if breathing difficulty occurs eye irritation occurs skin or scalp irritation continues or infection occurs Keep out of reach of children If swallowed, get medical help or contact a Poison Control Center right away.
Chemistry & Properties
| Formula | C19H30O5 |
|---|---|
| Molecular weight | 338.44 g/mol |
| IUPAC name | 5-[2-(2-butoxyethoxy)ethoxymethyl]-6-propyl-1,3-benzodioxole |
| CAS | 51-03-6 |
| PubChem CID | 5794 |
| InChIKey | FIPWRIJSWJWJAI-UHFFFAOYSA-N |
| logP | 3.72 (XLogP 3.7) |
| Polar surface area | 46.15 Ų |
| H-bond acceptors / donors | 5 / 0 |
| Drug-likeness (QED) | 0.51 |
| Lipinski violations | 0 |
SMILES
CCCCOCCOCCOCc1cc2c(cc1CCC)OCO2Biology & Pharmacokinetics
Pharmacokinetics predicted
| Bioavailability | 10.0% |
|---|---|
| Half-life | 0.35 h |
| Volume of distribution | 4.065 L/kg |
| Protein binding | 99.2% |
| BBB penetrant | Yes |
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP1A2 | Inhibitor | — |
| CYP1A2 | Substrate | — |
| CYP2B6 | Inhibitor | — |
| CYP2C19 | Inhibitor | — |
| CYP2C9 | Inhibitor | — |
| CYP2C9 | Substrate | — |
| CYP2D6 | Inhibitor | — |
| CYP2D6 | Substrate | — |
| CYP3A4 | Inhibitor | IC₅₀ 3.0000000000000013 µM |
| Cytochrome P450 | Moderate Inhibitor | — |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (1)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Licesol | Cream 2.70 g, 0.45 g | 150 g tube | MIDDLE EAST PHARMA&CHEMICAL IND/JORDAN | 3.240 |