New Release: Alpha testing version has been released.

Piperonyl Butoxide

P03A - Ectoparasiticides ATC P03AC52 Small molecule approved 2000 Topical Natural product

JFDA label: Licesol

Mechanism of Action

Inhibitor of Cytochrome P450 — Cytochrome P450 inhibitor

TargetActionGene / class
Cytochrome P450 efficacy INHIBITOR

Dosing

Source: openFDA

Directions Important: Read warnings before use Adults and children 2 years and over: Inspect check each household member with a magnifying glass in bright light for lice/nits (eggs) look for tiny nits near scalp, beginning at back of neck and behind ears examine small sections of hair at a time unlike dandruff which moves when touched, nits stick to the hair if either lice or nits are found, treat with this product Treat apply thoroughly to DRY HAIR or other affected area. For head lice, first apply behind ears and to back of neck. allow product to remain for 10 minutes, but no longer use warm water to form a lather, shampoo, then thoroughly rinse for head lice, towel dry hair and comb out tangles Remove lice and their eggs (nits) use a fine-tooth or special lice/nit comb. Remove any remaining nits by hand (using a throw-away glove). hair should remain slightly damp while removing nits if hair dries during combing, dampen slightly with water for head lice, part hair into sections. Do one section at a time starting on top of the head. Longer hair may take 1 to 2 hours. lift a 1-to 2-inch wide strand of hair. Place comb as close to scalp as possible and comb with a firm, even motion away from scalp. pin back each strand of hair after combing clean comb often. Wipe nits away with tissue and discard in a plastic bag. Seal bag and discard to prevent lice from coming back. after combing, thoroughly recheck for lice/nits. Repeat combing if necessary. check daily for any lice/nits that you missed a second treatment must be done in 7 to 10 days to kill any newly hatched lice if infestation continues, see a doctor for other treatments Children under 2 years : ask a doctor

Warnings & Precautions

Source: openFDA

Warnings & Precautions

Warnings For external use only Do not use near eyes inside nose, mouth, or vagina on lice in eyebrows or eyelashes. See a doctor if lice are present in these areas. Ask a doctor before use if you are allergic to ragweed. May cause breathing difficulty or an asthmatic attack. When using this product keep eyes tightly closed and protect eyes with a washcloth or towel if product gets into eyes, flush with water right away scalp itching or redness may occur Stop use and ask a doctor if breathing difficulty occurs eye irritation occurs skin or scalp irritation continues or infection occurs Keep out of reach of children If swallowed, get medical help or contact a Poison Control Center right away.

Chemistry & Properties

2D structure
FormulaC19H30O5
Molecular weight338.44 g/mol
IUPAC name5-[2-(2-butoxyethoxy)ethoxymethyl]-6-propyl-1,3-benzodioxole
CAS51-03-6
PubChem CID5794
InChIKeyFIPWRIJSWJWJAI-UHFFFAOYSA-N
logP3.72 (XLogP 3.7)
Polar surface area46.15 Ų
H-bond acceptors / donors5 / 0
Drug-likeness (QED)0.51
Lipinski violations0
SMILESCCCCOCCOCCOCc1cc2c(cc1CCC)OCO2

Biology & Pharmacokinetics

Pharmacokinetics predicted

Bioavailability10.0%
Half-life0.35 h
Volume of distribution4.065 L/kg
Protein binding99.2%
BBB penetrantYes

Enzyme interactions

EnzymeRoleDetail
CYP1A2Inhibitor
CYP1A2Substrate
CYP2B6Inhibitor
CYP2C19Inhibitor
CYP2C9Inhibitor
CYP2C9Substrate
CYP2D6Inhibitor
CYP2D6Substrate
CYP3A4Inhibitor IC₅₀ 3.0000000000000013 µM
Cytochrome P450Moderate Inhibitor

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (1)

BrandForm / strengthPackAgentCitizen (JOD)
Licesol Cream 2.70 g, 0.45 g 150 g tube MIDDLE EAST PHARMA&CHEMICAL IND/JORDAN 3.240