Pranoprofen
S01B - Antiinflammatory agents
ATC S01BC09
Small molecule
Natural product
JFDA label: Oftalar E/D
Indications
Off-label
Chemistry & Properties
| Formula | C15H13NO3 |
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| Molecular weight | 255.27 g/mol |
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| IUPAC name | 2-(5H-chromeno[2,3-b]pyridin-7-yl)propanoic acid |
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| CAS | 52549-17-4 |
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| PubChem CID | 4888 |
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| InChIKey | TVQZAMVBTVNYLA-UHFFFAOYSA-N |
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| logP | 2.97 (XLogP 2.7) |
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| Polar surface area | 59.42 Ų |
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| H-bond acceptors / donors | 3 / 1 |
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| Drug-likeness (QED) | 0.76 |
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| Lipinski violations | 0 |
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SMILES
CC(C(=O)O)c1ccc2c(c1)Cc1cccnc1O2Biology & Pharmacokinetics
Pharmacokinetics predicted
| Bioavailability | 10.0% |
|---|
| Half-life | 1.658 h |
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| Volume of distribution | 0.129 L/kg |
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| Protein binding | 97.9% |
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| BBB penetrant | No |
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Enzyme interactions
| Enzyme | Role | Detail |
|---|
| CYP2C9 | Substrate |
— |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)MRP2 (Inhibitor)MRP3 (Inhibitor)MRP4 (Inhibitor)OAT3 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (1)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|
| Oftalar E/D
|
Ophthalmic Solution 1 mg |
5 ml |
Jarzeem Drug Store |
3.290 |