Pyritinol
N06B - Psychostimulants, agents used for ADHD and nootropics
ATC N06BX02
Small molecule
Natural product
Withdrawn
Black-box warning
JFDA label: Encephabol syrup
⚠ Black-Box Warning
- Withdrawn: drug misuse — ChEMBL drug_warning (Withdrawn) | Bangladesh | evidence of insufficient therapeutic value and risk of misuse
Indications
Approved
- Attention Deficit Disorder with Hyperactivity — attention deficit hyperactivity disorder
Off-label
- Anxiety
- Dementia
- Depressive Disorder
- Schizophrenia
Chemistry & Properties
| Formula | C16H20N2O4S2 |
|---|---|
| Molecular weight | 368.48 g/mol |
| IUPAC name | 5-[[[5-hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridinyl]methyldisulfanyl]methyl]-4-(hydroxymethyl)-2-methylpyridin-3-ol |
| CAS | 1098-97-1 |
| PubChem CID | 14190 |
| InChIKey | SIXLXDIJGIWWFU-UHFFFAOYSA-N |
| logP | 2.57 (XLogP 1.2) |
| Polar surface area | 106.7 Ų |
| H-bond acceptors / donors | 8 / 4 |
| Drug-likeness (QED) | 0.44 |
| Lipinski violations | 0 |
SMILES
Cc1ncc(CSSCc2cnc(C)c(O)c2CO)c(CO)c1OBiology & Pharmacokinetics
Pharmacokinetics
| BBB penetrant | Yes |
|---|
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP1A2 | Inhibitor | — |
| CYP1A2 | Substrate | — |
| CYP2C19 | Inhibitor | — |
| CYP2C8 | Inhibitor | — |
| CYP2C9 | Substrate | — |
| CYP2D6 | Inhibitor | — |
| CYP2D6 | Substrate | — |
| CYP3A4 | Substrate | — |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (2)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Encephabol Tab | Tablet 100 mg | 20 tab pack varies | Merck KGaA | 3.020 |
| Encephabol syrup | Syrup 100 mg | 200 ml pack varies | Nabulsi Drug Store | 4.220 |