Rutoside

JFDA label: VENORUTON FORTE TAB

Indications

Off-label

• Cardiovascular Diseases
• Prostatic Neoplasms, Castration-Resistant
• Venous Thrombosis

Chemistry & Properties

Formula	C27H30O16
Molecular weight	610.52 g/mol
IUPAC name	2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
CAS	153-18-4
PubChem CID	5280805
InChIKey	IKGXIBQEEMLURG-NVPNHPEKSA-N
logP	-1.69 (XLogP -1.3)
Polar surface area	269.43 Ų
H-bond acceptors / donors	16 / 10
Drug-likeness (QED)	0.14
Lipinski violations	3

SMILES

C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O

Biology & Pharmacokinetics

Pharmacokinetics predicted

Bioavailability	70.0%
Half-life	4.616 h
Volume of distribution	0.873 L/kg
Protein binding	85.0%
BBB penetrant	No

Enzyme interactions

Enzyme	Role	Detail
CYP2C8	Inhibitor	—

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (2)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Pharmaton Capsules	Capsule 20 mg, 15 mg, 10 mg, 60 mg, 400 IU, 2 mg, 4000 IU, 1 mcg, 90.3 mg, 1 mg, 10 mg, 1 mg, 10 mg, 40 mg, 10 mg, 1 mg, 2 mg, 8 mg, 66 mg, 1 mg, 26 mg, 70 mg, 0.2 mg	30 cap	THE ARAB DRUG STORE P.S.C	6.700
VENORUTON FORTE TAB	Tablet 500 mg	30 tab	Nabulsi Drug Store	8.280