Salicylic Acid

D07X - Corticosteroids, other combinations ATC D02AF Small molecule Natural product

JFDA label: VERRUMAL Solution

Indications

Approved

Acne Vulgaris — acne
Callosities — keratosis
Dandruff — dermatitis
Dermatitis, Seborrheic — seborrheic dermatitis
Eye Diseases — eye inflammation
Inflammation — inflammation
Pruritus — Pruritus
Psoriasis — psoriasis
Skin Diseases — skin disease
Skin Neoplasms — skin cancer
Sunburn — sunburn
Warts — common wart

Off-label

Acute Coronary Syndrome
Cardiovascular Diseases
Headache
Heavy Metal Poisoning
Hypercholesterolemia
Infertility
Keratosis
Keratosis, Actinic
Pharyngitis
Stroke
Tension-Type Headache
Thrombophilia
Thrombosis

Adverse Reactions

Very Common >10%Common 1–10%Uncommon 0.1–1% Rare 0.01–0.1%Very Rare <0.01%Not Known

Vascular disorders (1)

Not Known Ecchymosis

Nervous system disorders (3)

Not Known Dizziness · Headache · Somnolence

Hepatobiliary disorders (1)

Not Known Hepatitis

Gastrointestinal disorders (10)

Not Known Abdominal discomfort · Abdominal pain upper · Constipation · Decreased appetite · Diarrhoea · Duodenal ulcer · Dyspepsia · Nausea · Oesophagitis · Vomiting

Skin and subcutaneous tissue disorders (7)

Not Known Dermatitis · Erythema · Erythema multiforme · Pruritus · Rash · Skin exfoliation · Urticaria

Psychiatric disorders (2)

Not Known Confusional state · Hallucination

Ear and labyrinth disorders (3)

Not Known Deafness · Hearing impaired · Tinnitus

Investigations (2)

Not Known Feeling abnormal · Weight increased

General disorders and administration site conditions (8)

Not Known Burning sensation · Dysgeusia · Gastric ulcer · Lethargy · Occult blood positive · Oedema · Pain · Skin papilloma

Respiratory, thoracic and mediastinal disorders (2)

Not Known Asthma · Epistaxis

Dosing

Source: openFDA

Directions Cleanse the skin thoroughly before applying medication. Cover the entire affected area with a thin layer one to three times daily. Because excessive drying of the skin may occur, start with one application daily, then gradually increase to two or three times daily if needed or as directed by a doctor. If bothersome dryness or peeling occurs, reduce application to once a day or every other day. Sensitivity Test for a New User. Apply product sparingly to one or two small affected areas during the first 3 days. If no discomfort occurs, follow the directions stated eleswhere on this label.

Warnings & Precautions

Source: openFDA

Warnings & Precautions

Warnings For external use only. When using this product skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Pregnancy & Lactation

Lactation

Compatible Hale L1

No information is available on the clinical use of salicylic acid on the skin during breastfeeding.

Chemistry & Properties

Formula	C7H6O3
Molecular weight	138.12 g/mol
IUPAC name	2-hydroxybenzoic acid
CAS	69-72-7
PubChem CID	338
InChIKey	`YGSDEFSMJLZEOE-UHFFFAOYSA-N`
logP	1.09 (XLogP 2.3)
Polar surface area	57.53 Å²
H-bond acceptors / donors	2 / 2
Drug-likeness (QED)	0.61
Lipinski violations	0

SMILES

O=C(O)c1ccccc1O

Biology & Pharmacokinetics

Pharmacokinetics

BBB penetrant	No (logBB -1.1)

Enzyme interactions

Enzyme	Role	Detail
CYP2C8	Inhibitor	—

Transporters

BCRP (Inhibitor)BCRP (Inhibitor)BSEP (Inhibitor)BSEP (Inhibitor)MATE1 (Inhibitor)MCT (Inhibitor)MCT1 (Inhibitor)MCT4 (Inhibitor)MRP1 (Inhibitor)MRP2 (Inhibitor)MRP4 (Inhibitor)OAT1 (Inhibitor)OAT2 (Inhibitor)OAT3 (Inhibitor)OAT4 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)OCT1 (Inhibitor)OCT2 (Inhibitor)P-gp (Inhibitor)MATE1 (Substrate)MATE2 (Substrate)MCT1 (Substrate)MDR1 (Substrate)MRP2 (Substrate)OATP1B1 (Substrate)OATP1B3 (Substrate)OATP2B1 (Substrate)P-gp (Substrate)

Registered Products (15)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Algesal Baume	Cream 6.540 g, 3.460 g	40 g tube pack varies	JERASH PHARMACEUTICALS LTD.CO/JORDAN	1.100
Beprosalic Ointment	Ointment 0.05 %, 2 %	15 g tube	Reda Jardaneh Drug Store	1.310
Pyralvex	Solution 1 %, of Rhubarb 5 %	10 ml	Khoury Drug Store	2.040
Salibet Ointment	Ointment 0.05 %, 3 %	30 g tube	شركة مستودع ادوية الايمان	2.280
Salidex Solution	Solution 20 mg, 1.2 mg	30 ml	PHILADELPHIA PHAEMACEUTICALS.COMP/JORDAN	2.400
Algesal Baume	Cream 6.540 g, 3.460 g	100 g tube pack varies	JERASH PHARMACEUTICALS LTD.CO/JORDAN	2.600
Emacort Topical Solution	Solution 2 %, 0.12 %	30 ml	JERASH PHARMACEUTICALS LTD.CO/JORDAN	2.610
psorianol oint	Ointment 0.1 %, 1 %	30 g tube	MIDDLE EAST PHARMA&CHEMICAL IND/JORDAN	2.880
VERRUMAL Solution	Solution 10 %, 0.5 %, 8 g	13 ml	Reda Jardaneh Drug Store	3.040
DIPROSALIC Ointment	Ointment 0.5 mg, 30 mg/g	30 g tube	Adatco Drug Store	3.250
Salicort Oint	Ointment 3 %, 0.12 %	30gm	Hayat Pharmaceutical Industries CO.PLC/JORDAN	3.460
Salidex Ointment	Ointment 3 %, 0.12 %	30 g tube	PHILADELPHIA PHAEMACEUTICALS.COMP/JORDAN	3.480
Mobilat-N	Cream 0.2 %, 2 %	50gm	Salam Drug Store	3.690
Emacort Ointment	Ointment 3 %, 1.2 mg/g	30 g tube	JERASH PHARMACEUTICALS LTD.CO/JORDAN	3.940
Elicasal	Cream 5 % %, 0.1 %	30 gm	شركة مستودع ادوية الايمان	5.600