Sodium
B05X - I.V. solution additives
ATC A06AG01
JFDA label: Klysmol Enema
Contraindications
Source: Lexicomp
- Hypernatremia and fluid retention Absolute
Adverse Reactions
Very Common >10%Common 1–10%Uncommon 0.1–1%
Rare 0.01–0.1%Very Rare <0.01%Not Known
Cardiac disorders (2)
Common Localized phlebitis · thrombosis
Metabolism and nutrition disorders (7)
Common Electrolyte disturbance (dilution of serum electrolytes) · hypernatremia · hypervolemia · hypocalcemia · hypokalemia · metabolic alkalosis · water intoxication
Gastrointestinal disorders (2)
Common Abdominal distention · flatulence
Respiratory, thoracic and mediastinal disorders (1)
Common Pulmonary edema
Dosing
Source: Lexicomp
Note: Sodium acetate is metabolized to bicarbonate on an equimolar basis outside the liver; administer in large volume IV fluids as a sodium source. Refer to Sodium Bicarbonate monograph. Maintenance electrolyte requirements of sodium in parenteral nutrition solutions: Daily requirements: 3-4 mEq/kg/24 hours or 25-40 mEq/1000 kcal/24 hours Maximum: 100-150 mEq/24 hours
(For additional information see "Sodium acetate: Pediatric drug information") Maintenance electrolyte requirements of sodium in parenteral nutrition solutions: IV: 3-4 mEq/kg/24 hours
Refer to adult dosing.
No dosage adjustment provided in manufacturer’s labeling. Use with caution.
No dosage adjustment provided in manufacturer’s labeling. Use with caution.
Warnings & Precautions
Source: Lexicomp
Hypernatremia
Close monitoring of serum sodium concentrations is needed to avoid hypernatremia. Disease-related concerns:
Acid/base disorders
Use with caution in patients with acid/base alterations; contains acetate, monitor closely during acid/base correction.
Edema
Use with caution in edematous patients.
Heart failure (HF)
Use extreme caution in patients with HF; monitor closely for edema.
Hepatic impairment
Use with caution in patients with severe hepatic impairment.
Renal impairment
Use with caution in patients with renal impairment; monitor serum sodium concentrations closely. Dosage form specific issues:
Aluminum
The parenteral product may contain aluminum; toxic aluminum concentrations may be seen with high doses, prolonged use, or renal dysfunction. Premature neonates are at higher risk due to immature renal function and aluminum intake from other parenteral sources. Parenteral aluminum exposure of >4 to 5 mcg/kg/day is associated with CNS and bone toxicity; tissue loading may occur at lower doses (Federal Register, 2002). See manufacturer’s labeling. Other warnings/precautions:
Extravasation
Avoid extravasation.
Pregnancy & Lactation
Pregnancy
FDA category C
Animal reproduction studies have not been conducted. Sodium requirements do not change during pregnancy (IOM, 2004).
Lactation
Sodium is found in breast milk. Sodium requirements do not change during lactation (IOM, 2004).
Chemistry & Properties
| Formula | Na |
|---|---|
| Molecular weight | 22.9897693 g/mol |
| IUPAC name | sodium |
| CAS | 7440-23-5 |
| PubChem CID | 5360545 |
| InChIKey | KEAYESYHFKHZAL-UHFFFAOYSA-N |
| H-bond acceptors / donors | 0 / 0 |
SMILES
[Na]Registered Products (40)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| 0.9% Sodium Chloride | Ampoule 0.9 % | 1 amp pack varies | Sabbagh Drug Store | 0.070 |
| 0.9% Sodium Chloride | Solution 0.9 % | 10 ml pack varies | Sabbagh Drug Store | 0.110 |
| Apectrolyte | Cream 1.5 g, 3.5 g, 2.9 g, 20 g | 28.2gm | Sahar Drug Store | 0.150 |
| 0.9% Sodium Chloride | Ampoule 0.9 % | 1 amp pack varies | Sabbagh Drug Store | 0.200 |
| Apisal eye nose drops | Ophthalmic Solution 9 mg/1 ml | 10 ml pack varies | Amman Pharmaceutical Indusries | 0.800 |
| PECTOLYN DECONGESTANT | Suspension 1.1 mg/5 ml, 57 mg/5 ml, 22.5 mg/5 ml, 14 mg/5 ml | 150 ml | Dar Al Dawa Development and Investment Co Ltd/Jordan | 0.850 |
| Babylyte | Solution 2.045 g, 0.98 g, 2.1620 g, 25 g | 240 ml | Sabbagh Drug Store | 1.020 |
| 0.9% Sodium Chloride | Ampoule 0.9 % | 20 amp pack varies | Sabbagh Drug Store | 1.190 |
| Apisal eye nose drops | Ophthalmic Solution 9 mg/1 ml | 15 ml pack varies | Amman Pharmaceutical Indusries | 1.200 |
| Klysmol Enema | Solution 21.28 g/133 ml, 7.98 g/133 ml | 133 ml | Al Hilal Drug Store | 1.480 |
| 0.9% Sodium Chloride | Ampoule 0.9 % | 70 amp pack varies | Sabbagh Drug Store | 1.510 |
| ORS New | Tablet 0.30 g, 0.52 g, 2.7 g, 0.58 g | 10 tab | Reda Jardaneh Drug Store | 1.540 |
| Burana | Sachet 500 mg | 10 SAC/1 BOX pack varies | Awtar Pharmaceutical Co | 1.720 |
| Midpharma Phosphate Enema B | Solution 8 %, 10 % | 128 ml | MIDDLE EAST PHARMA&CHEMICAL IND/JORDAN | 1.740 |
| 0.9% Sodium Chloride | Ampoule 0.9 % | 20 amp pack varies | Sabbagh Drug Store | 1.870 |
| Burana | Sachet 500 mg | 20 SAC/1 BOX pack varies | Awtar Pharmaceutical Co | 3.280 |
| 0.9% Sodium Chloride | Ampoule 0.9 % | 20 amp pack varies | Sabbagh Drug Store | 3.400 |
| Oral Rehydration salts(ORS) Powder | Powder 1.5 g, 3.5 g, 20 g, 2.9 g | 1 sachet | Reda Jardaneh Drug Store | 3.930 |
| SODIUM CHLORIDE AMP | Ampoule 9 mg/ml | 50 amp pack varies | Al Hilal Drug Store | 3.980 |
| SODIUM CHLORIDE AMP | Ampoule 9 mg/ml | 50 amp pack varies | Al Hilal Drug Store | 4.670 |
| Pariet Tablet | Tablet 10 mg | 14 tab | Al-Taqqadom Pharmaceutical Industries | 4.960 |
| Movicol Sachets | Sachet 0.047 g, 0.178 g, 0.351 g, 13.125 g | 20 sachet | Khoury Drug Store | 5.500 |
| 0.9% Sodium Chloride | Ampoule 0.9 % | 100 amp pack varies | Sabbagh Drug Store | 5.950 |
| Apisal Eye Oint. | Ointment 5 % | 5 g tube | Amman Pharmaceutical Indusries | 5.980 |
| 0.9% Sodium Chloride | Ampoule 0.9 % | 70 amp pack varies | Sabbagh Drug Store | 6.550 |
| Pariet Tab | Tablet 20 mg | 14 tab pack varies | Al-Taqqadom Pharmaceutical Industries | 8.130 |
| Fortrans | Sachet 0.75 g, 1.680 g, 1.460 g, 64 g, 5.700 g | 4 sachet | Abu Sharef Medical Stores | 8.190 |
| Moviprep | Sachet 1.015 g, 2.691 g, 4.7 g, 100 g, 5.9 g, 7.5 g | 2 sachet | Khoury Drug Store | 9.240 |
| 0.9% Sodium Chloride | Ampoule 0.9 % | 100 amp pack varies | Sabbagh Drug Store | 9.350 |
| Pariet Tab | Tablet 20 mg | 28 tab pack varies | Al-Taqqadom Pharmaceutical Industries | 15.170 |
| ALSAVISC | Pre-filled Syringe 8.5 mg, 20 mg, 0.045 mg, q.s, 0.28 mg | 1.1 ml | ALSANZA Medizintechink Und Pharma GMbH | — |
| Heparin Sodium Inj 25000I.U/5ml | Injection 3.00 mg/1 ml, 1.00 ml, 10000 mg/1 ml, 5000 IU/1 ml | 10 vial | THE ARAB DRUG STORE P.S.C | — |
| Olimel N12E | Solution Alanine 10.99 g/1000 ml, Arginine 7.44 g/1000 ml, L-Aspartic acid 2.20 g/1000 ml, Glutamic acid 3.79 g/1000 ml, Glycine 5.26 g/1000 ml, HISTIDINE 4.53 g/1000 ml, isoleucine 3.79 g/1000 ml, Leucine 5.26 g/1000 ml, Lysine acetate 8.43 g/1000 ml, methionine 3.79 g/1000 ml, phenylalanine 5.26 g/1000 ml, proline 4.53 g/1000 ml, Serine 3 g/1000 ml, threonine 3.79 g/1000 ml, Tryptophan 1.26 g/1000 ml, Tyrosine 0.2 g/1000 ml, valine 4.86 g/1000 ml, Sodium Acetate Trihydrate 1.5 g/1000 ml, Sodium Glycerophosphate (Liq 50 %) 3.67 g/1000 ml, Potassium Chloride 2.24 g/1000 ml, Magnesium Chloride Hexahydrate 0.81 g/1000 ml, Calcium Chloride Dihydrated 0.52 g/1000 ml, Glucose Monohydrate 80.67 g/1000 ml, Olive Oil 28 g/1000 ml, Soyabean Oil 7 g/1000 ml | 1000 ml | Khoury Drug Store | — |
| Olimel N12E | Solution Alanine 7.14 g/650 ml, Arginine 4.84 g/650 ml, L-Aspartic acid 1.43 g/650 ml, Glutamic acid 2.46 g/650 ml, Glycine 3.42 g/650 ml, HISTIDINE 2.94 g/650 ml, isoleucine 2.46 g/650 ml, Leucine 3.42 g/650 ml, Lysine acetate 5.48 g/650 ml, methionine 2.46 g/650 ml, phenylalanine 3.42 g/650 ml, proline 2.94 g/650 ml, Serine 1.95 g/650 ml, threonine 2.46 g/650 ml, Tryptophan 0.82 g/650 ml, Tyrosine 0.13 g/650 ml, valine 3.16 g/650 ml, Sodium Acetate Trihydrate 0.97 g/650 ml, Sodium Glycerophosphate (Liq 50 %) 2.39 g/650 ml, Potassium Chloride 1.45 g/650 ml, Magnesium Chloride Hexahydrate 0.53 g/650 ml, Calcium Chloride Dihydrated 0.34 g/650 ml, Glucose Monohydrate 52.43 g/650 ml, Olive Oil 18.2 g/650 ml, Soyabean Oil 4.55 g/650 ml | 650 ml | Khoury Drug Store | — |
| PeriOlimel N4E | Solution Arginine 3.72 g/1500 ml, L-Aspartic acid 1.1 g/1500 ml, Glutamic acid 1.90 g/1500 ml, Glycine 2.63 g/1500 ml, HISTIDINE 2.26 g/1500 ml, isoleucine 1.90 g/1500 ml, Leucine 2.63 g/1500 ml, Lysine acetate 4.21 g/1500 ml, methionine 1.90 g/1500 ml, phenylalanine 2.63 g/1500 ml, proline 2.26 g/1500 ml, Serine 1.5 g/1500 ml, threonine 1.9 g/1500 ml, Tryptophan 0.64 g/1500 ml, Tyrosine 0.1 g/1500 ml, valine 2.43 g/1500 ml, Sodium Acetate Trihydrate 1.73 g/1500 ml, Sodium Glycerophosphate (Liq 50 %) 2.87 g/1500 ml, Potassium Chloride 1.79 g/1500 ml, Magnesium Chloride Hexahydrate 0.67 g/1500 ml, Calcium Chloride Dihydrated 0.440 g/1500 ml, Glucose Monohydrate 123.75 g/1500 ml, Olive Oil 45 g/1500 ml, Soyabean Oil 45 g/1500 ml, Alanine 5.5 g/1500 ml | 1500 ml | Khoury Drug Store | — |
| Peritoneal dialysis | Tablet 538 mg, 5.08 mg, 25.7 mg, 1.5 mg | 2 l | مستودع ادوية الثائر | — |
| Peritoneal dialysis | Tablet 538 mg, 5.08 mg, 25.7 mg, 2.5 mg | 2 l | مستودع ادوية الثائر | — |
| Peritoneal dialysis | Tablet 538 mg, 5.08 mg, 25.7 mg, 4.25 mg | 2 l | مستودع ادوية الثائر | — |
| alsavisc1.8% | Pre-filled Syringe 8.5 mg, 20 mg, 0.045 mg, q.s, 0.28 mg | 1.1 ml | ALSANZA Medizintechink Und Pharma GMbH | — |
| hyalfid (Opthalmic Solution) | Ophthalmic Solution 0.380 %w/w, up to 100 %w/w, 0.2675 %w/w, 0.0752 %w/w, 0.1000 %w/w, 0.15 %w/w, 0.9500 %w/w, 0.0140 %w/w, 0.0108 %w/w | 10 ml | مستودع أدوية المتنبي | — |