Stearic Acid
J01 - Antibacterials for systemic use
Small molecule
Natural product
JFDA label: Osteoset T Bone graft Pellets with tobramycin
Chemistry & Properties
| Formula | C18H36O2 |
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| Molecular weight | 284.48 g/mol |
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| IUPAC name | octadecanoic acid |
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| CAS | 57-11-4 |
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| PubChem CID | 5281 |
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| InChIKey | QIQXTHQIDYTFRH-UHFFFAOYSA-N |
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| logP | 6.33 (XLogP 7.4) |
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| Polar surface area | 37.3 Ų |
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| H-bond acceptors / donors | 1 / 1 |
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| Drug-likeness (QED) | 0.34 |
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| Lipinski violations | 1 |
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SMILES
CCCCCCCCCCCCCCCCCC(=O)OBiology & Pharmacokinetics
Pharmacokinetics predicted
| Bioavailability | 70.0% |
|---|
| Half-life | 1.149 h |
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| Volume of distribution | 5.956 L/kg |
|---|
| Protein binding | 98.5% |
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| BBB penetrant | No |
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Enzyme interactions
| Enzyme | Role | Detail |
|---|
| CYP2B6 | Inhibitor |
— |
| CYP2B6 | Substrate |
— |
| CYP2C8 | Inhibitor |
— |
| CYP2C9 | Substrate |
— |
| CYP2D6 | Substrate |
— |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (1)