Strontium Ranelate

M05B - Drugs affecting bone structure and mineralization ATC M05BX03 Small molecule approved 2004 Natural product

JFDA label: Protelos Granules for susp

Mechanism of Action

— Unknown

Indications

Approved

Bone Diseases — bone disease
Osteoporosis, Postmenopausal — postmenopausal osteoporosis

Adverse Reactions

Very Common >10%Common 1–10%Uncommon 0.1–1% Rare 0.01–0.1%Very Rare <0.01%Not Known

Vascular disorders (1)

Very Common Embolism venous

Nervous system disorders (2)

Rare Dizziness · Paraesthesia

Hepatobiliary disorders (2)

Rare Hepatitis · Hepatobiliary disease

Blood and lymphatic system disorders (2)

Rare Eosinophilia · Pancytopenia

Immune system disorders (1)

Rare Hypersensitivity

Gastrointestinal disorders (10)

Rare Abdominal pain · Constipation · Dry mouth · Dyspepsia · Flatulence · Gastrointestinal disorder · Gastrointestinal pain · Gastrooesophageal reflux disease · Stomatitis · Vomiting

Skin and subcutaneous tissue disorders (10)

Rare Alopecia · Angioedema · Dermatitis · Erythema multiforme · Pruritus · Rash · Skin disorder · Stevens-Johnson syndrome · Toxic epidermal necrolysis · Urticaria

Musculoskeletal and connective tissue disorders (7)

Rare Arthralgia · Bone pain · Connective tissue disorder · Muscle spasms · Musculoskeletal discomfort · Musculoskeletal pain · Myalgia

Psychiatric disorders (3)

Rare Confusional state · Insomnia · Mental disorder

Ear and labyrinth disorders (1)

Rare Vertigo

Investigations (2)

Rare Body temperature increased · Feeling abnormal

General disorders and administration site conditions (11)

Rare Bronchial hyperreactivity · Discomfort · Drug eruption · Ill-defined disorder · Lymphadenopathy · Malaise · Mediastinal disorder · Mouth ulceration · Nervous system disorder · Oedema peripheral · Pain

Pregnancy & Lactation

Pregnancy

Chemistry & Properties

Formula	C12H6N2O8SSr2
Molecular weight	513.49 g/mol
IUPAC name	distrontium;5-[bis(carboxylatomethyl)amino]-3-(carboxylatomethyl)-4-cyanothiophene-2-carboxylate
CAS	135459-87-9
PubChem CID	6918182
InChIKey	`XXUZFRDUEGQHOV-UHFFFAOYSA-J`
logP	-0.08
Polar surface area	176.23 Å²
H-bond acceptors / donors	7 / 4
Drug-likeness (QED)	0.50
Lipinski violations	0

SMILES

N#Cc1c(N(CC(=O)[O-])CC(=O)[O-])sc(C(=O)[O-])c1CC(=O)[O-].[Sr+2].[Sr+2]

Biology & Pharmacokinetics

Pharmacokinetics predicted

Bioavailability	10.0%
Half-life	4.478 h
Volume of distribution	0.565 L/kg
Protein binding	57.1%
BBB penetrant	No

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)MRP2 (Inhibitor)MRP3 (Inhibitor)MRP4 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (1)

Brand	Form / strength	Pack	Agent	Citizen (JOD)
Protelos Granules for susp	Suspension 2 g	28 sachet	The Jordan Drugstore Co	32.470