Teprenone
V03A - All other therapeutic products
ATC V03AX
Unknown
JFDA label: Selbex Cap
Indications
Off-label
- Duodenal Ulcer
- Gastroesophageal Reflux
- Heart Failure
- Peptic Ulcer
Chemistry & Properties
| Formula | C23H38O |
|---|---|
| Molecular weight | 330.5 g/mol |
| IUPAC name | (5E,9E,13E)-6,10,14,18-tetramethylnonadeca-5,9,13,17-tetraen-2-one |
| CAS | 6809-52-5 |
| PubChem CID | 5282199 |
| InChIKey | HUCXKZBETONXFO-NJFMWZAGSA-N |
| logP | 7.4 (XLogP 7.4) |
| Polar surface area | 17.1 Ų |
| H-bond acceptors / donors | 1 / 0 |
SMILES
CC(=CCCC(=CCCC(=CCCC(=CCCC(=O)C)C)C)C)CBiology & Pharmacokinetics
Pharmacokinetics predicted
| Bioavailability | 10.0% |
|---|---|
| Half-life | 0.713 h |
| Volume of distribution | 0.992 L/kg |
| Protein binding | 96.3% |
| BBB penetrant | No |
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP2C19 | Substrate | — |
| CYP2D6 | Substrate | — |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (2)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Selbex Cap | Capsule 50 mg | 30 cap pack varies | Nairoukh Drug Store | 4.330 |
| Selbex Cap | Capsule 50 mg | 100 cap pack varies | Nairoukh Drug Store | 13.720 |