Tertatolol
C07A - Beta blocking agents
ATC C07AA16
Small molecule
Natural product
JFDA label: Artex Tab
Indications
Approved
- Cardiovascular Diseases — cardiovascular disease
Chemistry & Properties
| Formula | C16H25NO2S |
|---|
| Molecular weight | 295.45 g/mol |
|---|
| IUPAC name | 1-(tert-butylamino)-3-(3,4-dihydro-2H-thiochromen-8-yloxy)propan-2-ol |
|---|
| CAS | 83688-84-0 |
|---|
| PubChem CID | 36920 |
|---|
| InChIKey | HTWFXPCUFWKXOP-UHFFFAOYSA-N |
|---|
| logP | 2.85 (XLogP 2.7) |
|---|
| Polar surface area | 41.49 Ų |
|---|
| H-bond acceptors / donors | 4 / 2 |
|---|
| Drug-likeness (QED) | 0.88 |
|---|
| Lipinski violations | 0 |
|---|
SMILES
CC(C)(C)NCC(O)COc1cccc2c1SCCC2Biology & Pharmacokinetics
Pharmacokinetics predicted
| Bioavailability | 10.0% |
|---|
| Half-life | 0.434 h |
|---|
| Volume of distribution | 4.067 L/kg |
|---|
| Protein binding | 74.4% |
|---|
| BBB penetrant | Yes |
|---|
Enzyme interactions
| Enzyme | Role | Detail |
|---|
| CYP2C19 | Substrate |
— |
| CYP2D6 | Inhibitor |
— |
| CYP2D6 | Substrate |
— |
| CYP3A4 | Substrate |
— |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (1)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|
| Artex Tab
|
Tablet 5 mg |
30 tab |
The Jordan Drugstore Co |
5.360 |