New Release: Alpha testing version has been released.

Tetrahydrozoline

S01G - Decongestants and antiallergics ATC S01GA52

JFDA label: Apillerg eye drops

Dosing

Source: openFDA

Directions Directions adults and children 6 years of age and over: put 1 or 2 drops in the affected eye(s) up to 4 times a day children under 6 years of age: consult a doctor children under 2 years of age: do not use

Warnings & Precautions

Source: openFDA

Warnings & Precautions

Warnings For external use only. Ask a doctor before use Ask a doctor before use if you have narrow angle glaucoma. When using this product When using this product pupils may become enlarged temporarily overuse may cause more eye redness remove contact lenses before using replace cap after each use do not use if this solution changes color or becomes cloudy do not touch tip of container to any surface to avoid contamination Stop use and ask a doctor if Stop use and ask a doctor if you feel eye pain redness or irritation of the eye lasts changes in vision occur condition worsens or lasts more than 72 hours If pregnant or breast-feeding If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Pregnancy & Lactation

Pregnancy

Chemistry & Properties

2D structure
FormulaC13H16N2
Molecular weight200.28 g/mol
CAS84-22-0
PubChem CID5419
InChIKeyBYJAVTDNIXVSPW-UHFFFAOYSA-N
logP2.11
SMILESc1ccc2c(c1)CCCC2C1=NCCN1

Biology & Pharmacokinetics

Pharmacokinetics predicted

Bioavailability10.0%
Half-life2.15 h
Volume of distribution3.846 L/kg
Protein binding39.9%
BBB penetrantYes

Enzyme interactions

EnzymeRoleDetail
CYP1A2Substrate
CYP2C19Substrate
CYP2C9Substrate
CYP2D6Inhibitor
CYP2D6Substrate
CYP3A4Substrate

Transporters

BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)

Registered Products (3)

BrandForm / strengthPackAgentCitizen (JOD)
Apillerg eye drops Ophthalmic Solution 0.04 %, 0.05 % 10 ml Amman Pharmaceutical Industries Co 1.560
Phenidexoline Solution 0.5 %, 0.025 %, 0.1 % 10 ml Amman Pharmaceutical Industries Co 2.210
Efemyo Eye Drops Ophthalmic Solution 0.25 mg/ml, 1 mg/ml 10 ml Nabulsi Drug Store 3.440