Tetrahydrozoline
JFDA label: Apillerg eye drops
Dosing
Source: openFDA
Warnings & Precautions
Source: openFDA
Warnings & Precautions
Warnings For external use only. Ask a doctor before use Ask a doctor before use if you have narrow angle glaucoma. When using this product When using this product pupils may become enlarged temporarily overuse may cause more eye redness remove contact lenses before using replace cap after each use do not use if this solution changes color or becomes cloudy do not touch tip of container to any surface to avoid contamination Stop use and ask a doctor if Stop use and ask a doctor if you feel eye pain redness or irritation of the eye lasts changes in vision occur condition worsens or lasts more than 72 hours If pregnant or breast-feeding If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
Pregnancy & Lactation
Pregnancy
Chemistry & Properties
| Formula | C13H16N2 |
|---|---|
| Molecular weight | 200.28 g/mol |
| CAS | 84-22-0 |
| PubChem CID | 5419 |
| InChIKey | BYJAVTDNIXVSPW-UHFFFAOYSA-N |
| logP | 2.11 |
SMILES
c1ccc2c(c1)CCCC2C1=NCCN1Biology & Pharmacokinetics
Pharmacokinetics predicted
| Bioavailability | 10.0% |
|---|---|
| Half-life | 2.15 h |
| Volume of distribution | 3.846 L/kg |
| Protein binding | 39.9% |
| BBB penetrant | Yes |
Enzyme interactions
| Enzyme | Role | Detail |
|---|---|---|
| CYP1A2 | Substrate | — |
| CYP2C19 | Substrate | — |
| CYP2C9 | Substrate | — |
| CYP2D6 | Inhibitor | — |
| CYP2D6 | Substrate | — |
| CYP3A4 | Substrate | — |
Transporters
BCRP (Inhibitor)BSEP (Inhibitor)MRP1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B1 (Inhibitor)OATP1B3 (Inhibitor)P-gp (Inhibitor)P-gp (Substrate)
Registered Products (3)
| Brand | Form / strength | Pack | Agent | Citizen (JOD) |
|---|---|---|---|---|
| Apillerg eye drops | Ophthalmic Solution 0.04 %, 0.05 % | 10 ml | Amman Pharmaceutical Industries Co | 1.560 |
| Phenidexoline | Solution 0.5 %, 0.025 %, 0.1 % | 10 ml | Amman Pharmaceutical Industries Co | 2.210 |
| Efemyo Eye Drops | Ophthalmic Solution 0.25 mg/ml, 1 mg/ml | 10 ml | Nabulsi Drug Store | 3.440 |